|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.
|
24447396 |
2014 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes risk alleles in PPAR-γ2 (rs1801282) and PTPRD (rs17584499) are associated with pioglitazone therapeutic efficacy.
|
23147557 |
2013 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no convincing association between any polymorphism of PPARα and PPARγ and each individual component of the metabolic syndrome, except for the relationship of the P12A polymorphism with diabetes.
|
21877956 |
2012 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The interaction of the PPARγ Pro12Ala polymorphism with diabetes and cardiovascular risk is controversial.
|
22017455 |
2012 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of the PPARG2 Pro12Ala polymorphism and clinical risk factors for diabetes mellitus on HbA1c in the Japanese general population.
|
23006958 |
2012 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings shows the association of these two polymorphisms with serum triglyceride levels, which was increased in the order of P12P-CC < P12P-CT < P12A-CC < P12A-CT in the CHD patients with diabetes.
|
21833536 |
2011 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial.
|
21795447 |
2011 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors highlight these challenges and biases using an illustrative example: meta-analysis of interactions between the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene and various diet and lifestyle factors in the risk of diabetes.
|
20406760 |
2010 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala variant in the peroxisome proliferator-activated receptor gamma (PPARG) gene has been associated with diabetes and several cancers.
|
19436234 |
2009 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment.
|
17052804 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects.
|
17941898 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The P12A variant of isoform gamma is estimated to reduce diabetes risk by 19% in many populations, and has a large attributable risk because of high prevalence of the normal allele.
|
18388689 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
17763950 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The data did suggest that risk of cognitive decline is greater when Pro12A</span>la carriers contract diabetes.
|
18280041 |
2008 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adiponectin values did not differ among these two genotypes even when categorized based on their diabetes status (normal glucose tolerance Pro12Pro 7.9 vs. Pro12Ala 7.7 microg/ml, P = 0.994; diabetes Pro12Pro 4.7 vs. Pro12Ala 5.4 microg/ml, P = 0.622).
|
17335469 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
There appears to be certain genes which predispose Indians to diabetes while other genes (for example Pro 12 Ala polymorphism of PPAR gamma gene) which afford protection against diabetes and insulin resistance to Caucasians, do not appear to protect Indians.
|
17496355 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.
|
17563457 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index.
|
17213274 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals.
|
17898990 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
PPARG P12A (rs1801282) was not significantly associated with diabetes or related traits.
|
17903298 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic influence of PPARG P12A genotype is modest and is overshadowed by duration of diabetes and systolic blood pressure as the major risk factors for diabetic nephropathy in the Oji-Cree population.
|
17493550 |
2007 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Across all studies, the Pro12Ala polymorphism had no significant effect on diabetes-related traits.
|
17065690 |
2006 |