|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the impact of total energy intake on obesity in Pro12Ala</span> carriers seemed to be stronger than that in the wild-type genotype carriers.
|
30122193 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results support an important association between rs1805192 minor allele (G allele) of PPARG and increased DN risk; the interaction analysis showed a combined effect of interaction between rs1805192 and abdominal obesity on DN risk.
|
28013303 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results support an important association between rs1805192 and rs3856806 minor allele (G allele) of PPARG and increased T2DM risk, the interaction analysis shown a combined effect of G- obesity interaction between rs1805192 and obesity on increased T2DM risk.
|
28123453 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%.
|
27442659 |
2016 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population.
|
25182148 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combined results showed that PPAR-γ Pro1</span>2Ala polymorphism was associated with the obesit</span>y risk (Ala vs.
|
25502405 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis.
|
26361038 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors.
|
26185753 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction between Pro12Ala polymorphism of PPARγ2 and diet on adiposity phenotypes.
|
25342491 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index.
|
24827746 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98; 95% CI: 1.18-84.14, p=0.034).
|
24200052 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Concurrently, genotyping of the Pro12Ala polymorphism showed that obese subjects possess a significantly higher frequency of the Pro/Pro genotype than nonobese controls (90.5 vs 79.5%; P = 0.03), suggesting that this genotype is involved in an increased risk of obesity in the Tunisian population.
|
23315125 |
2013 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between PPARγ2 Pro12Ala polymorphism and myocardial infarction and obesity in Han Chinese in Hohhot, China.
|
22653647 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association.
|
22410809 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet.
|
22102511 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin.
|
19733160 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Many studies have focused on the physiological parameters and genetic predisposition of subjects presenting both obesity and insulin resistance (IR) and it has been suggested that the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) Pro12Ala variant may contribute to the observed variability in insulin sensitivity.
|
19645740 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis.
|
19766907 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment.
|
17052804 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity.
|
18280041 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding.
|
17624182 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of the C1431T silent mutation and the Pro12Ala missense transversion within the PPARgamma gene with the development of T2DM or obesity has often yielded contradictory results.
|
18250615 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have determined the Pro12Ala variant frequency in 370 nondiabetic Mexican Mestizo subjects and in five Mexican Amerindian groups and have investigated its possible association with lipid metabolism, insulin serum levels, and obesity in three of these populations.
|
17985660 |
2007 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations.
|
17439324 |
2007 |