|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism of PPARγ showed significant association with decreased PCOS susceptibility.
|
23748472 |
2013 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala PPAR γ2 gene polymorphism in PCOS women: the role of compounds regulating satiety.
|
21827375 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ultimately, sensitivity analysis demonstrated that, in total, there was no significant association between Pro12Ala polymorphism and PCO</span>S in the contrast of G allele versus C allele OR = 0.84 (95 % CI 0.69-1.04) and in Europeans, no significant association in the comparison of G allele versus C allele (OR = 0.84, 95 % CI 0.67-1.06) was also indicated.
|
22729915 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pro12Ala polymorphism was significantly associated with the susceptibility of PCOS (odds ratio [OR] 0.74, 95 % confidence interval [CI] [0.61, 0.90] for allele; OR 0.70, 95 % CI [0.57, 0.86] for genotype).
|
22527903 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the overall analysis, significant association between PPAR-γ2 Pro12Ala polymorphism and reduced risk of PCOS w</span>as observed (OR=0.75; 95%CI, 0.62-0.91; p=0.003).
|
22564702 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic analyses of the PPAR-gamma Pro12Ala and the PGC-1alpha Gly482Ser polymorphisms were performed in 184 patients with PCOS and 256 controls.
|
20130411 |
2010 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of the PPAR-gamma gene is not involved in the pathogenesis or the phenotypic expression of PCOS.
|
20045799 |
2010 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study has shown that both Pro12Ala and His447His polymorphisms of PPAR-gamma are associated with PCOS in a Korean population.
|
19549442 |
2009 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sequence analyses of the PPAR gamma gene indicated that neither the common polymorphisms P12A or H478 H, nor novel polymorphisms (E79Q, V32G, -39 T>C, c.480 +33 t > g,) or unique sequence variations (S22S, A23A, T41A, S226C, K272 T, I484I, c.819 +24 a>c) detected in this investigation revealed evidence for a direct association of PPAR gamma with altered IL-7, IL-1beta, IL-6 and TNFalpha levels in PCOS patients.
|
18680073 |
2008 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala and His447His genotypes did not influence risk of PCOS or its component phenotypes in patients with PCOS.
|
17141766 |
2007 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not find statistically significant differences with peroxisome proliferator-activated receptor-gamma2 Pro12Ala and peroxisome proliferator-activated receptor-gamma-1alpha Gly482Ser polymorphism distributions between Chinese women with PCOS and controls, or with body mass index and reproductive hormones among various genotypic groups of PCOS, suggesting that these genetic mutants did not have an effect on the susceptibility to PCOS.
|
16600233 |
2006 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
We suggest that Pro12Ala polymorphism of the PPAR-gamma gene may be a modifier of insulin resistance in women with PCOS.
|
16785159 |
2006 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that Pro12Ala PPAR-gamma gene polymorphism may be protective against IR and might prevent the development of diabetes mellitus in the first-degree relatives of subjects with PCOS.
|
16316841 |
2005 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism of the PPARgamma gene is associated with increased insulin sensitivity and lower hirsutism scores in PCOS women.
|
15853827 |
2005 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our results confirm that adiponectin concentrations are similar in PCOS and controls and demonstrate no effect of the PPAR-gamma gene Pro12Ala polymorphism on serum adiponectin levels.
|
15472214 |
2004 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro(12)Ala polymorphism at exon 2 was unrelated to BMI and/or leptin levels in PCOS women.
|
14671186 |
2003 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significantly different allele distribution of the Pro12 Ala polymorphism of the PPARgamma gene was observed between the two groups, with the frequency of the variant Ala isoform being significantly reduced in the PCOS group (12.6%) when compared with the control group (19.1%) (P = 0.045), at an odds ratio of 0.609 (95% confidence interval: 0.374-0.991).
|
12615821 |
2003 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that Pro(12)Ala in PPARG is a modifier of insulin resistance in Caucasian women with PCOS.
|
11836319 |
2002 |