BODY MASS INDEX, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
OBESITY, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
DIABETES MELLITUS, NONINSULIN-DEPENDENT, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
INTIMAL MEDIAL THICKNESS OF INTERNAL CAROTID ARTERY, MODIFIER OF
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D.
|
30064293 |
2018 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the impact of total energy intake on obesity in Pro12Ala</span> carriers seemed to be stronger than that in the wild-type genotype carriers.
|
30122193 |
2018 |
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphism in rs10865710, rs1805192 and rs4646903 and interaction between rs1805192 and rs4646903 were related with increased CAD susceptibility.
|
28415751 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest no significant association of p.Pro12Ala polymorphism with retinopathy in tested type 2 diabetic retinopathy patients as compared to T2DM individuals take as controls.
|
27427939 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found a significant association of Pro12Ala polymorphism of PPARγ2 gene with T2DM, however the genotypes showed statistically significant association only with few clinical parameters including body mass index, total cholesterol, and low-density lipoprotein (P < 0.05).
|
27567620 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results support an important association between rs1805192 and rs3856806 minor allele (G allele) of PPARG and increased T2DM risk, the interaction analysis shown a combined effect of G- obesity interaction between rs1805192 and obesity on increased T2DM risk.
|
28123453 |
2017 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results support an important association between rs1805192 minor allele (G allele) of PPARG and increased DN risk; the interaction analysis showed a combined effect of interaction between rs1805192 and abdominal obesity on DN risk.
|
28013303 |
2017 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results support an important association between rs1805192 and rs3856806 minor allele (G allele) of PPARG and increased T2DM risk, the interaction analysis shown a combined effect of G- obesity interaction between rs1805192 and obesity on increased T2DM risk.
|
28123453 |
2017 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%.
|
27442659 |
2016 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population.
|
25182148 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped PPARγ Pro12Ala polymorphism in subjects with type 2 diabetes mellitus (T2DM).
|
26836268 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes.
|
25974167 |
2015 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combined results showed that PPAR-γ Pro1</span>2Ala polymorphism was associated with the obesit</span>y risk (Ala vs.
|
25502405 |
2015 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis.
|
26361038 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variation in PPARG, but not Pro12Ala, contributes to declining SI and concomitant deterioration in β-cell function in Mexican Americans at risk for T2DM.
|
25584717 |
2015 |
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors.
|
26185753 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D).
|
25157153 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the independent and joint effects of PPARG Pro12Ala</span> and IRS1 Gly972Arg on markers of insulin resistance and T2DM in an African population with elevated risk of T2DM.</span>
|
24447396 |
2014 |