rs1805192, PPARG

N. diseases: 121
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
BODY MASS INDEX, MODIFIER OF
CUI: C1832251
Disease: BODY MASS INDEX, MODIFIER OF
0.700 SusceptibilityMutation CLINVAR
OBESITY, MODIFIER OF
CUI: C1832250
Disease: OBESITY, MODIFIER OF
0.700 SusceptibilityMutation CLINVAR
DIABETES MELLITUS, NONINSULIN-DEPENDENT, MODIFIER OF
0.700 SusceptibilityMutation CLINVAR
INTIMAL MEDIAL THICKNESS OF INTERNAL CAROTID ARTERY, MODIFIER OF
0.700 SusceptibilityMutation CLINVAR
Diabetes
CUI: C0011847
Disease: Diabetes
0.100 GeneticVariation BEFREE Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192). 31823921 2019
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192). 31823921 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D. 30064293 2018
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future. 29464546 2018
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE In addition, the impact of total energy intake on obesity in Pro12Ala</span> carriers seemed to be stronger than that in the wild-type genotype carriers. 30122193 2018
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.100 GeneticVariation BEFREE Polymorphism in rs10865710, rs1805192 and rs4646903 and interaction between rs1805192 and rs4646903 were related with increased CAD susceptibility. 28415751 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE These findings suggest no significant association of p.Pro12Ala polymorphism with retinopathy in tested type 2 diabetic retinopathy patients as compared to T2DM individuals take as controls. 27427939 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We found a significant association of Pro12Ala polymorphism of PPARγ2 gene with T2DM, however the genotypes showed statistically significant association only with few clinical parameters including body mass index, total cholesterol, and low-density lipoprotein (P < 0.05). 27567620 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Our results support an important association between rs1805192 and rs3856806 minor allele (G allele) of PPARG and increased T2DM risk, the interaction analysis shown a combined effect of G- obesity interaction between rs1805192 and obesity on increased T2DM risk. 28123453 2017
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Our results support an important association between rs1805192 minor allele (G allele) of PPARG and increased DN risk; the interaction analysis showed a combined effect of interaction between rs1805192 and abdominal obesity on DN risk. 28013303 2017
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Our results support an important association between rs1805192 and rs3856806 minor allele (G allele) of PPARG and increased T2DM risk, the interaction analysis shown a combined effect of G- obesity interaction between rs1805192 and obesity on increased T2DM risk. 28123453 2017
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%. 27442659 2016
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population. 25182148 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We genotyped PPARγ Pro12Ala polymorphism in subjects with type 2 diabetes mellitus (T2DM). 26836268 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes. 25974167 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The combined results showed that PPAR-γ Pro1</span>2Ala polymorphism was associated with the obesit</span>y risk (Ala vs. 25502405 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis. 26361038 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Variation in PPARG, but not Pro12Ala, contributes to declining SI and concomitant deterioration in β-cell function in Mexican Americans at risk for T2DM. 25584717 2015
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. 26185753 2015
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D). 25157153 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE We investigated the independent and joint effects of PPARG Pro12Ala</span> and IRS1 Gly972Arg on markers of insulin resistance and T2DM in an African population with elevated risk of T2DM.</span> 24447396 2014