|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study suggested that individuals carrying rs2004640 T allele correlated with a high risk of SLE, and the IRF5 rs2004640 polymorphism was associated with SLE susceptibility.
|
31347288 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
|
31018759 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients.
|
30168487 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of the rs20</span>04640 T allele increases the risk of nephritis development in Egyptian children with SLE.
|
28059021 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nevertheless, two haplotypes based on the 3 variants [exon6(in/de), rs10954213, rs2004640] of IRF5 (DAG and IAT) could define protective or susceptibility haplotype in SLE.
|
26294277 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The novelty of this study is the association of the rs2004640 T-allele with increased anti-dsDNA antibody production and SLE in a younger age group.
|
24697591 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IRF5 haplotype (rs729302 A, rs2004640 T, and rs2280714 T), which was reported as conferring an increased risk of SLE, was significantly associated with MAS susceptibility in patients with systemic JIA (OR 4.61; 95% CI 1.73, 12.3; p < 0.001).
|
21239750 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a subgroup analysis by ethnicity, significantly increased SLE risk was associated with IRF5 rs2004640 T allele in populations of European, Asian and Latin American origin, and the rs10954213 A allele is significantly associated with SLE in European origin but not in Asian origin.
|
21834935 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
|
19043711 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control association study was performed for rs2004640 as well as for rs10954213 and rs2280714, all of which were previously reported to be associated with SLE, in 281 SSc patients and 477 healthy controls.
|
19479858 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CGGGG indel explains the association signal from multiple SNPs in the IRF5 gene, including rs2004640, rs10954213 and rs729302 previously considered to be causal variants in SLE.
|
18063667 |
2008 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results in an independent case-control sample confirm the robust association of the IRF5/rs2004640 T allele with SLE risk, and further support the relevance of the type I interferon system in the pathogenesis of SLE and autoimmunity.
|
17166181 |
2007 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotypes carrying the T alleles of rs2004640 and rs2280714 and the A allele of rs10954213 are over-transmitted in SLE families.
|
17189288 |
2007 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
In combined analysis, including all seven independent cohorts from the three studies so far, robust and consistent associations of the rs2004640 T allele with SLE were observed.
|
17389033 |
2007 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis.
|
17158136 |
2007 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine whether specific isoforms of IRF5 are transcribed in patients with systemic lupus erythematosus (SLE) who have risk genotypes in the exon 1B donor splice site at single-nucleotide polymorphism (SNP) no. rs2004640.
|
17393452 |
2007 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two genetic variants of the IRF5 gene (rs2004640 in exon 1 and rs2280714 in the 3'-untranslated region) have been shown to exert functional modifications affecting IRF5 messenger RNA splicing and expression, and have been associated with genetic predisposition to systemic lupus erythematosus (SLE).
|
17133578 |
2006 |
|
Lupus Erythematosus, Systemic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we convincingly replicate association of the IFN regulatory factor 5 (IRF5) rs2004640 T allele with SLE in four independent case-control cohorts (P = 4.4 x 10(-16)) and by family-based transmission disequilibrium test analysis (P = 0.0006).
|
16642019 |
2006 |