|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
The G2677T T and C3435T T alleles as well as the TT, CTT and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in our population.
|
29198163 |
2018 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
On the other hand, C allele and CC genotype of C1236T and C3435T, as well as G allele and GG genotype of G2677T/A were more frequent in healthy subjects, implying protective role of these variants in UC.
|
29543864 |
2018 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Similarly, the genotype distribution of 3435C>T and 2677G>T/A SNPs was not significantly different between Polish and Bosnian patients with CD (p > 0.05).
|
28759738 |
2017 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
The association between the non-synonymous polymorphism G2677T/A in the coding region of the ABCB1 gene, and the risk of resistance to anti-epileptic drugs (AEDs) in epilepsy remains controversial.
|
26220385 |
2015 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
rs776746 and rs15524 in the CYP3A5 gene tend to affect CBZ metabolism, and rs2032582, rs10234411 in the ABCB1 gene may contribute to inter-individual variation in CBZ and in CBZ-E transport among patients with epilepsy using CBZ in combination with PHT or PB.
|
26421491 |
2015 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results suggest that MDR1 C3435T and G2677T/A polymorphisms are not associated with AED resistance in Turkish epileptic patients.
|
24213830 |
2014 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
In this study, we analyzed whether the three single nucleotide polymorphisms (C1236T, G2677T/A, and C3435T) in the ABCB1 gene were associated with pharmacoresistant epilepsy in a western Chinese pediatric population.
|
21420937 |
2011 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
No significant association was found between G2677T/A polymorphism and epilepsy drug resistance in the different subgroups of patients.
|
21636342 |
2011 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy.
|
18812236 |
2009 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNPs), C3435T and G2677T/A, thought to alter the function of the corresponding P-glycoprotein, have shown inconsistent associations with CD.
|
19107781 |
2009 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Heterozygous carriers for the variants C1236T, rs2235046 (an SNP in intron 16), and G2677T/A showed a lower risk of developing ulcerative colitis (C1236T: odds ratio [OR] = 0.63, 95% confidence interval [CI] = 0.42-0.93, P = 0.03; G2677T/A: OR = 0.59, CI = 0.39-0.89, P = 0.02; and rs2235046: OR = 0.59, 95% CI = 0.38-0.91, P = 0.009) as compared with homozygotes.
|
19685447 |
2009 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Three-marker (C1236T, G2677T/A, C3435T) and two-marker (C1236T, G2677T/A) haplotype analysis revealed significant associations with UC (TTT, P=0.04; TGT, P=0.01; TT, P=0.01; CT, P=0.03).
|
19005421 |
2009 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
In this study, the G2677T/A polymorphism observed in the MDR1 gene was not found to be a risk factor for Crohn's disease or ulcerative colitis.
|
19115152 |
2008 |
|
Epilepsy
|
|
0.080 |
GeneticVariation
|
BEFREE |
Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification.
|
17924830 |
2007 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium.
|
17206635 |
2007 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
No significant association between G2677T/A polymorphism and any specific subphenotypes was found, nor was there any association with subphenotypic categories of UC and both single nucleotide polymorphisms.
|
17260353 |
2007 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD).
|
17262810 |
2007 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects.
|
17260353 |
2007 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC).
|
16374256 |
2006 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC).
|
16374256 |
2006 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
Ulcerative Colitis
|
|
0.080 |
GeneticVariation
|
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Crohn Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Colorectal Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Therefore, we aimed to investigate the relationship between colorectal cancer and the functional common variants of ABCB1 (1236C > T; 2677G > T/A; 3435C > T).
|
23193993 |
2013 |