|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In summary, our findings suggested that the rs2046210 polymorphism may serve as a potential genetic biomarker of BC in both Asians and Caucasians.
|
30693664 |
2019 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The other two SNPs (rs2046210 and rs3734805) were strongly associated with susceptibility to breast cancer.
|
27525837 |
2016 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a genome-wide association study conducted among Chinese women, we identified the single nucleotide polymorphism (SNP) rs2046210 at 6q25.1 for breast cancer risk.
|
26645718 |
2016 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer.
|
26803517 |
2016 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
|
27354352 |
2016 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, C6ORF97 showed significant worse prognostic values especially in luminal B subtype in the publically available data sets. rs2046210 and the upstream gene C6ORF97 might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients, which suggests that functional studies of this locus are imperative.
|
25370037 |
2015 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The results indicated that both polymorphisms were significantly associated with the risk of breast cancer, with per allele OR = 1.35, (95%CI = 1.17-1.57) for rs2046210 and per allele OR = 1.24 (95%CI = 1.06-1.45) for rs4784227.
|
25531440 |
2014 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Despite some limitations, this meta-analysis demonstrates that the rs2046210 polymorphism may be a risk factor associated with increased breast cancer risk.
|
23609471 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests the participation of rs2046210 at 6q25.1 in the susceptibility for BC, especially in Europeans and Asians.
|
23888322 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In joint analyses that included both SNPs, the rs2046210-A allele was associated with increased risk of breast cancer [odds ratio (OR) = 1.14; 95% confidence interval (CI) = 1.02-1.28], and the rs2046211-G allele was associated with reduced risk (OR = 0.80; 95% CI = 0.67-0.95).
|
23104177 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present meta-analysis demonstrated that the rs2046210 polymorphism may be associated with increased BC susceptibility, but this association varies in different ethnicities.
|
23785413 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women.
|
24289300 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings emphasized the proof of principle that multiple interactions of genetic variants, including rs3757318, rs2046210, and rs4973768 may play important roles in the susceptibility of BC though the biological mechanisms underlying the observed associations need to be elucidated.
|
24265035 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
|
23544013 |
2013 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans, although the biological mechanisms need to be further investigated.
|
23272245 |
2012 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05).
|
22452962 |
2012 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Overall, all of the five SNPs contributed to breast cancer susceptibility in a dominant genetic model (2q35, rs13387042: adjusted OR = 1.26, P = 0.006; 3q24.1, rs2307032: adjusted OR = 1.24, P = 0.005; 6q22.33, rs2180341: adjusted OR = 1.22, P = 0.006; 6q25.1, rs2046210: adjusted OR = 1.51, P = 2.40 × 10-8; 10q26.13, rs2981582: adjusted OR = 1.31, P = 1.96 × 10-4).
|
22269215 |
2012 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study identified a novel single nucleotide polymorphism (SNP), rs2046210, in the 6q25 region as a breast cancer susceptibility locus in Chinese and subsequently replicated in a multicenter study.
|
21528353 |
2011 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs2046210, linked to an increased risk of breast cancer, was associated with increased but not statistically significant risk of endometrial cancer (OR = 1.16, 95% CI = 0.96-1.41 for the GA and AA genotypes compared with the GG genotype); the association was stronger among post-menopausal women (OR = 1.28, 95% CI = 1.00-1.65).
|
21272446 |
2011 |
|
Breast Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 × 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 × 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031).
|
21593217 |
2011 |