|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies suggested an association between two single nucleotide polymorphisms (T45G and G276T) of the ADIPOQ gene that encodes for the hormone adiponectin and PCOS susceptibility.
|
31122534 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition to these factors, metabolic syndrome may also be related to genetic factors, the ADIPOQ + 45T> G polymorphism has been associated with serum adiponectin levels, insulin sensitivity, and obesity, which affects adiponectin levels act as protective factor for cardiovascular disease.
|
29313754 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, our findings indicated that rs266729, rs822395, rs1501299 and rs</span>2241766 polymorphisms were all significantly associated with the susceptibility to CAD in c</span>ertain populations.
|
30879388 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs1501299 and rs2241766 polymorphisms both affect the susceptibility to CAD in certain populations.
|
30885128 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The net effects of T45G polymorphism on the MAO phenotype may be achieved by changes in the adiponectin oligomer ratio and glucose levels.
|
27236826 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
|
29686595 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2241766T>G SNP of adiponectin gene is a risk factor for the development of T2DM in Iraqi population and directs the changes of serum lipid concentrations as well as insulin resistance.
|
29627525 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control study was conducted to assess the association of rs2241766 and rs822395 SNPs of adiponectin gene (ADIPOQ) with T2DM in Iraqi population.
|
29627525 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North-African population from Tunisia.
|
29633340 |
2018 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs1501299 and rs2241766 polymorphisms might serve as genetic biomarkers of PCOS in certain ethnicities.
|
30509295 |
2018 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2241766 polymorphism is found to be associated with a significant increase in CAD risk in Caucasian and genotyping method (PCR-RFLP) subgroups.
|
28881706 |
2017 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that the SNPs +45T>G (rs2241766), -4034A>C (rs822395), and -11391G>A (rs17300539) were linked to CAD development.
|
28617663 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
LEP rs7799039, LEPR rs1137101, and ADIPOQ rs2241766 and 1501299 Polymorphisms Are Associated With Obesity and Chemotherapy Response in Mexican Women With Breast Cancer.
|
28416193 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results show that T45G and G276T polymorphisms of ADPN are associated with a significantly elevated risk of DPN in T2DM patients, likely by down-regulating ADPN serum level.
|
26144281 |
2016 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype analysis showed that the minor allele (G) frequency of rs2241766 ADIPOQ was statistically significant in the CAD group compared with the control group [odds ratio (OR), 2.779; 95% confidence interval (CI), 1.403-5.504; P=0.003].
|
27218147 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study, the associations of rs2241766 T/G of ADIPOQ, rs9289231 T/G of KALRN, and rs9939609 A/T of FTO polymorphisms with genetic susceptibility to CAD in type 2 diabetic (T2D) patients were investigated.
|
27218147 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adiponectin rs2241766T/G and rs17300593G/A rather than rs1501299G/T and rs266729C/G polymorphisms were associated with the risk of DN in T2DM, especially in the Caucasian population.
|
24825737 |
2015 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, we failed to find significant overtransmission of the other SNP, rs2241766, from parents to PCOS offspring.
|
24559720 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis suggest that the ADIPOQ-rs2241766 G/T polymorphism might be associated with obesity in Chinese studies but not in non-Chinese studies in adults.
|
24740426 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Better-designed studies that consider confounding factors and assess larger sample sizes with a focus on ADIPOQ-rs2241766G/T polymorphisms and obesity are required in the future.
|
24740426 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Together, our data support that the rs2241766 and rs1501299 polymorphisms within the ADIPOQ gene confer genetic susceptibility for type 2 diabetes, especially in the Chinese Han population.
|
25135112 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further, the ADIPOQ g. + 45 T > G and TNF-α g. - 308 G > A polymorphisms jointly give 1.45-fold risk towards T2D.
|
24655058 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there is no association between rs2241766 and obesity risk.
|
25223469 |
2014 |
|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype TGTG from adiponectin gene variants 45T/G and 276G/T is related to susceptibility to PCOS, and might be associated with increased blood pressure in PCOS.
|
23685884 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recruited in total 594 subjects; 462 patients with angiographically confirmed coronary artery disease (CAD) and 132 controls matched for age and gender. rs2241766 and rs1501299 were genotyped by polymerase chain reaction and restriction endonuclease digestion.
|
23041095 |
2013 |