rs2294008, PSCA;JRK

N. diseases: 28
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.860 GeneticVariation BEFREE Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. 27001215 2016
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.860 GeneticVariation BEFREE The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)). 22387998 2012
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.860 GeneticVariation BEFREE Frequency of PSCA rs2294008 C/C genotype in duodenal ulcer was 36.1%, which was significantly higher than those with gastric cancer (12.4%), gastric ulcer (19.0%), gastritis (10.7%), and H. pylori-negatives (19.5%) (p < .001). 25582162 2015
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.860 GeneticVariation BEFREE Genomic DNA from 603 Spanish patients with primary GC, 139 with DU and 675 healthy controls was typed for the PSCA rs2294008C>T polymorphism by PCR-TaqMan assays. 25721731 2015
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.860 GeneticVariation BEFREE Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7). 30407486 2019
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.860 GeneticVariation BEFREE Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population. 31839644 2019
Duodenal Ulcer
CUI: C0013295
Disease: Duodenal Ulcer
0.860 GeneticVariation BEFREE From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians. 25721731 2015
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC. 28220687 2017
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively. 20083643 2010
Malignant neoplasm of urinary bladder
0.800 GeneticVariation BEFREE Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. 26308216 2015
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with GC susceptibility and in linkage disequilibrium. 22426141 2012
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.800 GeneticVariation BEFREE In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development. 25117309 2014
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously. 22387998 2012
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. 27001215 2016
Malignant neoplasm of urinary bladder
0.800 GeneticVariation BEFREE For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer. 28881685 2017
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele-adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33-0.77; P = .002). 24962126 2014
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene. 25727947 2015
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04). 29028942 2017
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). 31839644 2019
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE Two single nucleotide polymorphisms (SNPs) (rs2976392 and rs2294008) in the PSCA gene were recently identified as the susceptibility loci of gastric cancer, especially in diffuse type. 20131315 2010
Malignant neoplasm of urinary bladder
0.800 GeneticVariation BEFREE In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors. 22416122 2012
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.800 GeneticVariation BEFREE Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer. 31008939 2019
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer. 22481254 2012
Carcinoma of bladder
CUI: C0699885
Disease: Carcinoma of bladder
0.800 GeneticVariation BEFREE Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity. 25374226 2014
Stomach Carcinoma
CUI: C0699791
Disease: Stomach Carcinoma
0.800 GeneticVariation BEFREE The rs2294008 polymorphism in PSCA increases the risk of noncardia gastric cancer and its precursors in white individuals but protects against proximal cancers. 21070776 2011