Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04).
|
29028942 |
2017 |
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer.
|
27001215 |
2016 |
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2.41, 95% CI: 1.03-5.66; recessive, OR: 2.80, 95 % CI: 1.21-6.47) and postmenopausal women (allele model, OR: 1.29, 95% CI: 1.01-1.65).
|
27050280 |
2016 |
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
When stratified by clinicopathologic features, the T allele of rs2294008 was associated with progesterone receptor status (homozygote model, OR: 1.98, 95% CI: 1.08-3.63; recessive, OR: 1.87, 95% CI: 1.04-3.37), and the rs2976392 polymorphism was associated with high lymph node metastasis risk in homozygote model (OR: 2.09, 95%CI: 1.01-4.31).
|
27050280 |
2016 |
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer.
|
27001215 |
2016 |
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer.
|
27001215 |
2016 |
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2.41, 95% CI: 1.03-5.66; recessive, OR: 2.80, 95 % CI: 1.21-6.47) and postmenopausal women (allele model, OR: 1.29, 95% CI: 1.01-1.65).
|
27050280 |
2016 |
Mucosal atrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the influence of the PSCA rs2294008 C>T polymorphism on susceptibility to H. pylori-related diseases and the relationships between PSCA polymorphism and gastric mucosal atrophy.
|
25582162 |
2015 |
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overall, in the present study SNPs of PSCA (rs2294008, rs2976392), MUC1 (rs4072037) and PLCE1 (rs2274223) genes were not associated with the presence of CRC.
|
26320491 |
2015 |
Adenocarcinoma Of Esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of interest, the association of rs2294008 with ESCC was consistent with that observed in esophageal adenocarcinoma and ESCC in Caucasian populations.
|
24654646 |
2014 |
Squamous cell carcinoma of esophagus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of interest, the association of rs2294008 with ESCC was consistent with that observed in esophageal adenocarcinoma and ESCC in Caucasian populations.
|
24654646 |
2014 |
Gallbladder Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
PSCA gene variants (rs2294008 and rs2978974) confer increased susceptibility of gallbladder carcinoma in females.
|
23988503 |
2013 |
Gastric ulcer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU).
|
31839644 |
2019 |
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Therefore, this meta-analysis suggested that the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms might be associated with cancer susceptibility, which might act as a potential predicted biomarker for genetic susceptibility to cancer, especially in gastric cancer and bladd er cancer.
|
28881685 |
2017 |
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Therefore, this meta-analysis suggested that the PSCA rs2294008 C>T and rs2976392 G>A polymorphisms might be associated with cancer susceptibility, which might act as a potential predicted biomarker for genetic susceptibility to cancer, especially in gastric cancer and bladd er cancer.
|
28881685 |
2017 |
Intestinal metaplasia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The genotypes (TT, TC and CC) of PSCA single nucleotide polymorphism rs2294008 among H. pylori infected and uninfected Bhutanese were compared with the severity of H. pylori-related gastritis [neutrophils, monocytes, atrophy scores, H. pylori density, and the presence and extent of intestinal metaplasia (IM)] using the updated Sydney system.
|
26706772 |
2016 |
Gastric ulcer
|
|
0.020 |
GeneticVariation
|
BEFREE |
The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer.
|
25582162 |
2015 |
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
Intestinal metaplasia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The T allele of rs2294008 was found to be associated with a higher prevalence of atrophic gastritis (OR = 1.44; 95% CI 1.03-2.01 for the dominant model) and intestinal metaplasia (OR = 1.50; 95% CI 1.13-1.98 for the dominant model).
|
24023815 |
2013 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
In addition, our data indicate that rs2294008 of PSCA is involved in GC susceptibility and confer its effect primarily in noncardia tumors (OR = 1.30, 95% CI 1.12-1.53, P < 10(-4)).
|
24146278 |
2014 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Smoking habits, tumor grade and tumor stage did not modify the association between rs2294008 and the risk of bladder cancer.
|
25374226 |
2014 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
The study suggests that anti-PSCA immunotherapy might be beneficial for bladder cancer patients with high tumor PSCA expression, which is statistically significantly associated with the presence of CT and TT genotypes of a common genetic variant, rs2294008.
|
23266392 |
2013 |
Carcinogenesis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
Carcinogenesis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.
|
25374226 |
2014 |