Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene.
|
25727947 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer.
|
25582162 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians.
|
25721731 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU).
|
25721731 |
2015 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively.
|
25658482 |
2015 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
|
25117309 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele-adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33-0.77; P = .002).
|
24962126 |
2014 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.
|
25374226 |
2014 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.
|
25374226 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
|
25503145 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In addition, our data indicate that rs22</span>94008 of PSCA is involved in GC susceptibility and confer its effect primarily in noncardia tumors (OR = 1.30, 95% CI 1.12-1.53, P < 10(-4)).
|
24146278 |
2014 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that the T allele of rs2294008, an intronic variant of the PSCA gene at 8q24 that was previously associated with an increased risk of gastric cancer, was inversely associated with a decreased risk of ESCC (odds ratio = 0.90; 95% confidence interval, 0.81-0.99; P = 0.034).
|
24654646 |
2014 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
|
25117309 |
2014 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We analyzed 3 SNPs in the PSCA gene (rs2294008, rs9297976 and rs12155758) which were previously found to be associated with GC risk in Europeans.
|
24023815 |
2013 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
The study suggests that anti-PSCA immunotherapy might be beneficial for bladder cancer patients with high tumor PSCA expression, which is statistically significantly associated with the presence of CT and TT genotypes of a common genetic variant, rs2294008.
|
23266392 |
2013 |
Carcinoma of bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
The study suggests that anti-PSCA immunotherapy might be beneficial for bladder cancer patients with high tumor PSCA expression, which is statistically significantly associated with the presence of CT and TT genotypes of a common genetic variant, rs2294008.
|
23266392 |
2013 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The two loci of PSCA (rs2294008 and rs2976392) were both significantly associated with GC susceptibility and in linkage disequilibrium.
|
22426141 |
2012 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10(-33)) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10(-12)), as reported previously.
|
22387998 |
2012 |
Malignant neoplasm of urinary bladder
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors.
|
22416122 |
2012 |
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
|
22481254 |
2012 |