rs25487, XRCC1

N. diseases: 205
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE APEX1 rs3136817, MUTYH rs3219493, three SNPs (rs3213356, rs25487 and rs1799782) in XRCC1, and three SNPs (rs1799794, rs861531 and rs861530) in XRCC3 showed significant associations with the risk of bladder cancer. 27153553 2016
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk. 25501209 2014
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE The analysis suggests that the XRCC1 Arg399Gln polymorphism might be a moderate risk factor for bladder cancer, especially in non-Asian population. 24176953 2014
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE We conducted a meta-analysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population. 23704969 2013
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE The meta-analysis results suggest that XRCC1 Arg194Trp and Arg399Gln polymorphisms may be associated with elevated bladder cancer risk. 23496911 2013
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE This meta-analysis suggests that the XRCC1 R399Q polymorphism may play a protective role against bladder cancer among smokers. 24039945 2013
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE The overall data failed to indicate significant associations between XRCC1 A</span>rg399Gln polymorphism and bladder cancer risk (Gln/Gln versus Arg/Arg: odds ratio (OR) = 0.97; 95% CI = 0.85-1.10; dominant model: OR = 1.02; 95% CI = 0.94-1.09; recessive model: OR = 0.95; 95% CI = 0.84-1.07). 23479765 2013
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE Significant increased risk of bladder cancer was observed for Arg194Trp polymorphism (allele comparison OR = 1.20, 95 % CI: 1.06-1.36, P heterogeneity = 0.11; dominant model OR = 1.20, 95 % CI: 1.02-1.41, P heterogeneity = 0.37) and Arg280His polymorphism (heterozygote comparison OR = 1.87, 95 % CI: 1.21-2.90, P heterogeneity = 0.01; dominant model OR = 1.75, 95 % CI: 1.05-2.90, P heterogeneity = 0.01); however, Arg399Gln was not associated with susceptibility to bladder cancer. 23636799 2013
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls. 22927776 2012
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility. 18336890 2008
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE It indicated that XRCC1 R399Q and R194W might not be risk factors to bladder cancer, but the 399QQ genotype decreased susceptibility of bladder cancer under recessive model and homozygote contrast among ever-smokers. 18765423 2008
Bladder Neoplasm
CUI: C0005695
Disease: Bladder Neoplasm
0.100 GeneticVariation BEFREE Our data are consistent with a potential role of the XRCC1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis, repaired by the base excision repair mechanism, that are not directly associated with tobacco smoking. 15298955 2004