Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study indicated that the XRCC1 rs25487 was a risk factor for the susceptibility of HCC, which was verified by the TSA.
|
31478224 |
2020 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Urinary 8-hydroxydeoxyguanosine in relation to XRCC1 rs25487 G/A (Arg399Gln) and OGG1 rs1052133 C/G (Ser326Cys) DNA repair genes polymorphisms in patients with chronic hepatitis C and related hepatocellular carcinoma.
|
31354343 |
2019 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Similarly, a significant association between XRCC1 Arg399Gln and HCC risk was found in healthy controls in the general population but not in hospital controls.
|
30408066 |
2018 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
On univariate analysis, a statistically significant association was found between risk of HCC and XRCC1 399Arg/Gln genotype (odd ratio [OR] = 1.88; 95% CI, 1.04-3.43), which was confirmed after adjusting by sex (OR = 1.94; 95% CI, 1.04-3.63).
|
28058700 |
2017 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XRCC1 rs25487 polymorphisms are prognostic for HCC patients receiving TACE.
|
26918371 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subgroup analyses revealed significant association of XRCC1 gene Arg399Gln with hepatocellular carcinoma in Chinese especially from south China (odds ratio, 95% confidence interval, P: 1.57, 1.16-2.14, 0.004), in larger studies (1.48, 1.11-1.98, 0.007) and in studies with population-based controls (1.33, 1.06-1.68, 0.016).
|
27306318 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our analysis suggested that the variant genotypes of the XRCC1 Arg399Gln gene were associated with a significantly increased risk of HCC in a co-dominant model (Arg/Gln vs. Arg/Arg, odd ratios [OR] 1.39, 95 % confidence interval [CI] 1.08-1.79; Gln/Gln vs. Arg/Arg, OR 1.26, 95 % CI 1.04-1.52) and a dominant model (Arg/Gln + Gln/Gln vs. Arg/Arg OR 1.36, 95 % CI 1.07-1.72), whereas no association was observed in the recessive model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.05, 95 % CI 0.91-1.21).
|
24390232 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We explored the association between 4 XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) polymorphisms with the development and prognosis of hepatocellular carcinoma (HCC).
|
24938468 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This updated meta-analysis results suggest that XRCC1 Arg399Gln variants may contribute to HCC risk.
|
24969866 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that XRCC1 Arg399Gln polymorphism may increase HCC risk especially among Asians.
|
24815482 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests the participation of XRCC1 Arg399Gln is a genetic susceptibility for hepatocellular cancer in Asians and breast cancer in Indians.
|
24205095 |
2013 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis of the available data did not find an obvious effect of XRCC1 Arg399Gln polymorphism on hepatitis-related hepatocellular carcinoma.
|
23780894 |
2013 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results from the present meta-analysis indicated that the Arg399Gln polymorphisms of XRCC1 may be a genetic susceptibility for HCC in the East Asian population.
|
23055199 |
2013 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, no potential contribution of XRCC1 Arg399Gln polymorphism to HCC susceptibility in HBV/HCV subgroups was identified.
|
24289575 |
2013 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The XRCC1 Arg194Trp and Arg399Gln polymorphisms are not associated with HCC risk.
|
22919255 |
2012 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the Chinese Han population, the XRCC1 Arg399Gln gene polymorphism is associated with an increased hepatocellular carcinoma risk.
|
23098440 |
2012 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association is found between the XRCC1 polymorphism Arg399Gln and the risk of HCC.
|
21645210 |
2011 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interestingly, the risk for HCC was further enhanced by 35.96 (95% CI = 11.64-110.91; P < 0.001) and 5.28 times (95% CI = 2.81-9.09; P < 0.001) when the genotype Arg280His was found in association with Arg194Trp and Arg399Gln, respectively.
|
19194663 |
2009 |