rs25489, XRCC1

N. diseases: 78
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE Several potential functional polymorphisms in the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln (rs25487), Arg194Trp (rs1799782), Arg280His (rs25489) and X-ray repair cross-complementing group 3 (XRCC3) T241M (rs861539) have been implicated in colorectal cancer (CRC) risk, but the results are conflicting. 23271134 2013
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE Several potential functional polymorphisms in the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln (rs25487), Arg194Trp (rs1799782), Arg280His (rs25489) and X-ray repair cross-complementing group 3 (XRCC3) T241M (rs861539) have been implicated in colorectal cancer (CRC) risk, but the results are conflicting. 23271134 2013
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE The Arg280His polymorphism modified the association between alcohol consumption and colorectal cancer risk (interaction P = 0.049). 22186158 2012
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP Val742Ala; and XRCC1 Arg194Trp, Arg280His, Arg399Gln) as potential CRC risk factors and modifiers of the association between diets high in red meat or poultry and CRC risk. 21037106 2010
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.040 GeneticVariation BEFREE No association is found between the polymorphisms in XRCC1 (Arg399Gln, Arg280His, and Arg194Trp) and risk of colorectal cancer. 20033188 2010