rs25489, XRCC1

N. diseases: 78
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma. 26843108 2017
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE The rs25489 A/G genotype was also significantly associated with increased risk of glioma when compared with the A/A genotype (OR = 1.52; 95%CI = 1.03-2.35). 24634177 2014
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg194Trp, Arg280His, and Arg399Gln may be associated with the individual susceptibility to glioma. 24048757 2014
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE This meta-analysis suggests that there may be no association between the Arg280His polymorphism and glioma risk, whereas the Arg399Gln/Arg194Trp polymorphisms may contribute to genetic susceptibility to glioma in the Chinese population. 25375625 2014
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE This study demonstrates that the rs25489 (Arg280His) and Arg399Gln (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population. 25245010 2014
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities. 23383237 2013
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg399Gln, Arg194Trp, and Arg280His have drawn attention because of their potential associations with the development of glioma. 23712607 2013
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE The rs2276466 G/G genotype was significantly associated with a moderate increased risk of glioma (OR=1.82, 95% CI=1.10-3.02) in a codominant model, and variation of rs25489 was associated with a 1.31- and 1.78-fold glioma risk in dominant and recessive models, respectively. 23911298 2013
Glioma
CUI: C0017638
Disease: Glioma
0.090 GeneticVariation BEFREE A total of 11 studies (3,810 cases and 6,079 controls), 7 studies (2,928 cases and 5,048 controls), and 4 studies (1,461 cases and 2,593 controls) were finally included in the analyses of the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and glioma risk, respectively. 23167420 2012