rs2736100, TERT

N. diseases: 83
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis. 29536006 2018
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE The TERT rs2736100 polymorphism was associated with increased overall cancer risk in five genetic models [homozygous model (GG vs. TT): odds ratio (OR) = 1.39, 95% confidence interval (95% CI) = 1.26-1.54, P < 0.001; heterozygous model (TG vs. TT): OR = 1.16, 95% CI = 1.11-1.23, P < 0.001; dominant model (TG + GG vs. TT): OR = 1.23, 95% CI = 1.15-1.31, P < 0.001; recessive model (GG vs. TG + TT): OR = 1.25, 95% CI = 1.16-1.35, P < 0.001; and allele contrast model (G vs. T): OR = 1.17, 95% CI = 1.12-1.23, P < 0.001]. 28418878 2017
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE For rs2736100, the cancer risk genotype CC was significantly associated with a reduced incidence of TERT promoter mutations compared to AA + AC variants [Odds ratio (OR): 0.181, 95% Confidence interval (CI): 0.0543-0.601, P = 0.004]. 28416747 2017
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE We genotyped telomerase reverse transcriptase (TERT) rs2736100 variants, the SNP associated with a risk of multiple-types of cancer, in patients with UTUC (n = 212) and evaluated the relationship between the rs2736100 and UTUC risk by comparing to 289 healthy controls. 26934125 2016
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE Increased cancer risk was found between TERT-rs2736100, as well as CLPTM1L-rs402710 and cancer susceptibility. 23707794 2013
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE In all genetic models, the association between the TERT rs2736100 polymorphism and cancer risk was significant. 22221621 2012
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE The rs2736100 association demonstrates an influence of variation at 5p15.33 on CRC risk and further evidence that the 5p15.33 (TERT-CLPTM1L) locus has pleiotropic effects (reflecting generic or lineage-specific effects) on cancer risk. 22878375 2012