rs2736100, TERT

N. diseases: 83
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Specific single nucleotides polymorphisms (SNPs) rs4977756 (CDKN2A/B), rs6010620 (RTEL1), rs498872 (PHLDB1), rs2736100 (TERT), and rs4295627 (CCDC26) have been associated with glioma susceptibility and are potential risk biomarkers. 31721021 2020
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASCAT Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility. 30714141 2019
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25). 26243184 2016
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Taken together, these data suggested that TERT rs2736100 polymorphism may contribute to glioma susceptibility. 24888789 2014
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASDB Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 24908248 2014
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASCAT Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 24908248 2014
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE The role of telomerase reverse transcriptase (TERT) in gliomagenesis has been recently further strengthened by the frequent occurrence of TERT promoter mutations (TERTp-mut) in gliomas and evidence that the TERT SNP genetic rs2736100 influences glioma risk. 25314060 2014
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Case-control analyses stratified into 4 molecular classes (defined by 1p-19q status, IDH mutation, and EGFR amplification) showed an association of rs4295627 and rs498872 with IDH-mutated gliomas (P < 10(-3)) and rs2736100 and rs6010620 with IDH wild-type gliomas (P < 10(-3) and P = .03). 23161787 2013
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE In analyses including glioma cases with a family history of brain tumours (n = 104) and control subjects free of glioma at baseline, three of seven SNPs were associated with glioma risk: rs2736100 (5p15.33, TERT), rs4977756 (9p21.3, CDKN2A-CDKN2B) and rs6010620 (20q13.33, RTEL1). 23115063 2013
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Four of the five SNPs previously reported by others were statistically significantly associated with increased risk of glioma in our study (rs2736100, rs4295627, rs4977756, and rs6010620); rs498872 was not associated with glioma in our study. 23903690 2013
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASCAT Genome-wide association study of glioma and meta-analysis. 22886559 2012
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASDB Genome-wide association study of glioma and meta-analysis. 22886559 2012
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR). 21825990 2011
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASDB Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk. 21827660 2011
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASCAT Chromosome 7p11.2 (EGFR) variation influences glioma risk. 21531791 2011
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASCAT Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk. 21827660 2011
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASDB Chromosome 7p11.2 (EGFR) variation influences glioma risk. 21531791 2011
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)). 21350045 2011
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk. 20462933 2010
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872). 20212223 2010
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk. 20847058 2010
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASDB We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation BEFREE We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Glioma
CUI: C0017638
Disease: Glioma
0.900 GeneticVariation GWASCAT We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367 2009
Adenocarcinoma of lung (disorder)
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
0.880 GeneticVariation GWASCAT Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. 27501781 2016