rs3077, HLA-DPA1

N. diseases: 16
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE Our results demonstrated, for the first time, that expression of HLA-DPA1 alleles and rs3077 affected the risk of HBV infection. 30267609 2019
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated. 29300980 2018
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE No significant correlation was shown in HLA-DP rs3077 and rs9277535 with HBV infection or liver function recovery (P < .05).Our study concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ rs7453920 was related to prognosis of liver transplant recipients. 28640108 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine. 28882445 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE The HLA-DPA1 rs3077 variant was associated with a protective effect increasing the spontaneously resolved HBV infection (OR 0.64, 95% CI 0.41-0.98, P=0.039, dominant genetic model). 27051043 2016
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE Japanese patients (202) who were hepatitis B e antigen positive at baseline, received LAM as first-line treatment, and consented to HLA-DP genotyping (HLA-DPA1 rs3077 and HLA-DPB1 rs9277535) were categorized into two cohorts, viz., a cohort who achieved virological response without rescue therapy (cohort 1) and those who did so with rescue therapy (cohort 2). 25103089 2015
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE We found that rs3077 and rs9277535 in HLA-DP significantly decreased HBV infection risks and increased HBV clearance possibility in a dose-dependent manner. 26462556 2015
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported. 25041342 2015
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE The association study between rs3077 and HCC susceptibility was performed in four independent comparisons that contained 1871 cases with hepatitis B virus (HBV)-related HCC and 3207 carriers with persistent HBV. 26634522 2015
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE Both rs3077 and rs2284553 polymorphisms were not associated with HBV viral load in terms of allelic frequency, genotypic frequency, dominant/recessive gene action. rs9808753 (G allele) was associated with a reduced chance of "undetectable HBV DNA" for patients below the age of 50 years in allelic frequency analysis (odds ratio 0.562; 95% confidence interval, 0.326-0.967; P value = 0.037). 23980639 2014
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE The results showed that rs2856718, rs3077, rs9277535 and rs9275572 were associated with HBV infection (p = 0.0003, OR = 1.351, CI = 1.147-1.591; p = 0.041, OR = 1.20, CI = 1.007-1.43; p = 0.045, OR = 1.198, CI = 1.004-1.43 and p = 0.0018, OR = 0.776, CI = 0.662-0.910, respectively). 24465366 2014
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. 23825586 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation GWASDB A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. 23760081 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection. 23326374 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE We aimed to determine the effect of HLA-DP polymorphisms on the generation of HBV mutations and their interactions on the outcomes of HBV infection. rs3077, rs3135021, rs9277535, and rs2281388 were genotyped in 1,342 healthy controls, 327 HBV clearance subjects, and 2,736 HBV-positive subjects, including 1,108 hepatocellular carcinoma (HCC) patients, using quantitative PCR. 24006435 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE Our analysis indicated a significant association of rs3077 and rs9277535 in HLA-DP with HBV infection, suggesting that these HLA-DP polymorphisms act beneficially against HBV infection (for rs3077, AG vs. GG: OR = 0.522, 95% CI = 0.485-0.561; AA vs. GG: OR = 0.350, 95% CI = 0.311-0.393; for rs9277535, AG vs. GG: OR = 0.542, 95% CI = 0.506-0.579; AA vs. GG: OR = 0.371, 95% CI = 0.336-0.409). 23601003 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations. 22105689 2012
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians. 22448225 2012
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation GWASDB Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. 22737229 2012
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation GWASCAT Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. 22737229 2012
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE The results of meta-analysis pooling all eligible studies also showed that rs3077-A and rs9277535-A alleles were associated with an increased clearance rate to HBV infection (rs3077: OR=0.57, 95% CI=0.44-0.75; rs9277535: OR=0.56, 95% CI=0.47-0.63). 22543033 2012
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation GWASCAT A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. 21750111 2011
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation GWASDB A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. 21750111 2011
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation BEFREE HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. 21402545 2011
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.900 GeneticVariation GWASDB A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. 19349983 2009