Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 2
0.700 SusceptibilityMutation CLINVAR
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural "fear network". 31734525 2019
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE The more active T allele of the functional rs324981 variant in the neuropeptide S receptor gene (NPSR1) is associated with panic disorder (PD) and distorted cortico-limbic activity during emotion processing in healthy adults and PD patients. 26503268 2017
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE In recent years, accumulating data from various labs have demonstrated an A/T single-nucleotide polymorphism (SNP) resulting in (Asn107Ile) switch in the human NPSR gene as the risk factor for various psychiatric disorders such as panic disorder, post traumatic syndrome, alcohol use disorders and enhanced anxiety sensitivity, although, this is in stark contrast to the findings made in animal models which have consistently projected the anxiolytic nature of this peptide system. 26680586 2016
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE Neuropeptide S is involved in anxiety and arousal modulation, and the functional polymorphism Asn107Ile (rs324981, A > T) of the neuropeptide S receptor gene (NPSR1) is associated with panic disorder and anxiety/fear-related traits. 24331455 2014
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE A coding variation (Asn107Ile) of the NPS receptor gene (NPSR1) was associated with panic disorder and schizophrenia. 23680103 2013
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE The T allele of rs324981, which goes along with enhanced receptor function, was associated with panic disorder, increased anxiety sensitivity in healthy subjects, attenuated prefrontal brain activation and elevated amygdala responses to fear-relevant stimuli. 23103692 2013
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE A functional variant within this gene leads to an amino-acid exchange (rs324981, Asn107Ile) resulting in a gain-of-function in the Ile107 variant which was recently associated with panic disorder in two independent studies. 22078257 2012
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety sensitivity. 21525857 2011
Panic Disorder
CUI: C0030319
Disease: Panic Disorder
0.090 GeneticVariation BEFREE The more active NPSR rs324981 T allele was found to be associated with panic disorder in the female subgroup of patients in both samples as well as in a meta-analytic approach. 20603625 2011
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.070 GeneticVariation BEFREE Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms. 27990720 2017
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.070 GeneticVariation BEFREE In recent years, accumulating data from various labs have demonstrated an A/T single-nucleotide polymorphism (SNP) resulting in (Asn107Ile) switch in the human NPSR gene as the risk factor for various psychiatric disorders such as panic disorder, post traumatic syndrome, alcohol use disorders and enhanced anxiety sensitivity, although, this is in stark contrast to the findings made in animal models which have consistently projected the anxiolytic nature of this peptide system. 26680586 2016
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.070 GeneticVariation BEFREE Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders. 22404660 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.070 GeneticVariation BEFREE Since stress is critically involved in the pathogenesis of anxiety disorders, we tested the association between rs324981 and stress reactivity in 196 healthy males. 23466585 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.070 GeneticVariation BEFREE The current results are in line with earlier imaging genetic studies and suggest a potential protective function of the NPSR1 rs324981 A/A genotype against pathologically enhanced anxiety that might be explained by stronger reflective prefrontal regulation over the subcortical fear response. 23103692 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.070 GeneticVariation BEFREE All subjects were genotyped for the functional NPSR1 A/T (Asn(107)Ile) variant (rs324981) and characterized for anxiety sensitivity using the Anxiety Sensitivity Index (ASI). 23319044 2013
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.070 GeneticVariation BEFREE Thereby, NPSR rs324981 apparently causes an indirect effect on anxiety-related traits and potentially contributes to the pathogenesis of anxiety disorders by shaping fear-related limbic activity. 21525857 2011
Anxiety
CUI: C0003467
Disease: Anxiety
0.060 GeneticVariation BEFREE Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms. 27990720 2017
Anxiety
CUI: C0003467
Disease: Anxiety
0.060 GeneticVariation BEFREE In recent years, accumulating data from various labs have demonstrated an A/T single-nucleotide polymorphism (SNP) resulting in (Asn107Ile) switch in the human NPSR gene as the risk factor for various psychiatric disorders such as panic disorder, post traumatic syndrome, alcohol use disorders and enhanced anxiety sensitivity, although, this is in stark contrast to the findings made in animal models which have consistently projected the anxiolytic nature of this peptide system. 26680586 2016
Anxiety
CUI: C0003467
Disease: Anxiety
0.060 GeneticVariation BEFREE Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders. 22404660 2014
Anxiety
CUI: C0003467
Disease: Anxiety
0.060 GeneticVariation BEFREE All subjects were genotyped for the functional NPSR1 A/T (Asn(107)Ile) variant (rs324981) and characterized for anxiety sensitivity using the Anxiety Sensitivity Index (ASI). 23319044 2013
Anxiety
CUI: C0003467
Disease: Anxiety
0.060 GeneticVariation BEFREE The current results are in line with earlier imaging genetic studies and suggest a potential protective function of the NPSR1 rs324981 A/A genotype against pathologically enhanced anxiety that might be explained by stronger reflective prefrontal regulation over the subcortical fear response. 23103692 2013
Anxiety
CUI: C0003467
Disease: Anxiety
0.060 GeneticVariation BEFREE Thereby, NPSR rs324981 apparently causes an indirect effect on anxiety-related traits and potentially contributes to the pathogenesis of anxiety disorders by shaping fear-related limbic activity. 21525857 2011
Asthma
CUI: C0004096
Disease: Asthma
0.030 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) close to the gain-of-function substitution, Asn(107)Ile (rs324981, A>T), in Neuropeptide S Receptor 1 (NPSR1) have been associated with asthma. 28463995 2017
Asthma
CUI: C0004096
Disease: Asthma
0.030 GeneticVariation BEFREE Notably, this inhibition is absent in the asthma-linked N107I variant of NPSR, suggesting that residue 107 interacts with the aforementioned regulatory region of NPS. 16790440 2006