rs34637584, LRRK2

N. diseases: 78
Disease: Sense of smell impaired ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Sense of smell impaired
CUI: C2364082
Disease: Sense of smell impaired
0.040 GeneticVariation BEFREE Participants belonging to the following cohorts of the Parkinson Progression Markers Initiative (PPMI) study were included: de novo PD with dopamine transporter binding deficit (n = 423), idiopathic REM sleep behavior disorder (RBD, n = 39), hyposmia (n = 26) and non-PD mutation carrier (NMC; Leucine-rich repeat kinase 2 (LRRK2) G2019S (n = 88) and glucocerebrosidase (GBA) gene (n = 38) mutations)). 30125297 2018
Sense of smell impaired
CUI: C2364082
Disease: Sense of smell impaired
0.040 GeneticVariation BEFREE University of Pennsylvania Smell Identification Test (UPSIT) scores in LRRK2-G2019S-PD were higher than those in IPD (23.5±6.8 vs 18.4±6.0; p = 0.002), and hyposmia was less frequent in G2019S carriers than in IPD (39.4% vs 75.8%; p = 0.01). 25330404 2014
Sense of smell impaired
CUI: C2364082
Disease: Sense of smell impaired
0.040 GeneticVariation BEFREE The proportion of hyposmic individuals was not statistically different in patients with PD-G2019S (50%) and iPD (82%), but hyposmia was significantly less common in both AsG2019S+ (26%) and AsG2019S- (28%). 23325906 2013
Sense of smell impaired
CUI: C2364082
Disease: Sense of smell impaired
0.040 GeneticVariation BEFREE Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data. 18809839 2008