Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Mitochondrial abnormalities
CUI: C4020732
Disease: Mitochondrial abnormalities
0.040 GeneticVariation BEFREE LRRK2 pathophysiology remains unclear, but reduced dopamine and mitochondrial abnormalities occur in aged G2019S mutant knock-in (GKI) mice. 28930069 2017
Mitochondrial abnormalities
CUI: C4020732
Disease: Mitochondrial abnormalities
0.040 GeneticVariation BEFREE Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. 23529190 2013
Mitochondrial abnormalities
CUI: C4020732
Disease: Mitochondrial abnormalities
0.040 GeneticVariation BEFREE Mitochondrial abnormalities are a common feature in PD pathogenesis and we have investigated the impact of G2019S mutant LRRK2 expression on mitochondrial bioenergetics. 22736029 2012
Mitochondrial abnormalities
CUI: C4020732
Disease: Mitochondrial abnormalities
0.040 GeneticVariation BEFREE In addition, we observe autophagic and mitochondrial abnormalities in the brains of aged G2019S LRRK2 mice and markedly reduced neurite complexity of cultured dopaminergic neurons. 21494637 2011