Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models. 31188929 2019
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014). 29390492 2017
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Therefore, <i>MTHFR</i> C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL. 28392709 2017
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE The aim of our study was to investigate the influence of C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene on MTX-induced toxicity during treatment of children with ALL. 26528799 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Our findings suggest that MTHFR C677T and A1298C polymorphisms are unlikely to affect the development of childhood ALL in an Egyptian population from Delta. 25629981 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL. 25115513 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE The aims of this study were to (a) to determine the prevalence of seven common genetic polymorphisms including those that affect the folate and/or thiopurine metabolic pathways, i.e. cyclin D1 (CCND1-G870A), γ-glutamyl hydrolase (GGH-C452T), methylenetetrahydrofolate reductase (MTHFR-C677T and MTHFR-A1298C), thymidylate synthase promoter (TYMS-TSER), thiopurine methyltransferase (TPMT*3A and TPMT*3C) and inosine triphosphate pyrophosphatase (ITPA-C94A), in Caucasian (n = 94, age < 20) and Vietnamese (n = 141, age < 16 years) childhood ALL and (b) to assess the impact of a multilocus genetic risk score (MGRS) on relapse-free survival (RFS) using a Cox proportional-hazards regression model. 25099492 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE To evaluate the effects of the genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) on childhood ALL risk in Taiwan, two well-known polymorphic genotypes of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed to examine the extent of their associations with childhood ALL susceptibility and to discuss the MTHFR genotypic contribution to childhood ALL risk among different populations. 25793509 2015
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In conclusion, the MTHFR C677T and A1298C haplotypes might be useful for monitoring adverse effects in childhood ALL maintenance therapy in Japanese patients. 23865834 2014
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE However, a significant association was detected between the MTHFR A1298C/ RFC G80A genotype and a nonpredisposition for ALL (P = 0.035). 24237708 2014
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Two polymorphisms of the gene encoding MTHFR, C677T and A1298C, alter MTHFR enzyme activity and may be associated with ALL relapse. 24637499 2014
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn. 25342508 2014
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In conclusion, MTHFR, C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity in pediatric ALL. 23089671 2013
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE These results suggest that the MTHFR C677T, but not A1298C, polymorphism is a potential biomarker for childhood ALL risk. 21495160 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE 5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL). 22943282 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE The A1298C polymorphism had an effect on ALL risk neither in adults (Dominant model: OR(FE)=0.95, 95% CI: 0.71-1.27, p=0.72) nor in children (Dominant model: OR(FE)=1.02, 95% CI: 0.87-1.21, p=0.77). 23061880 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE In total, 167 children with ALL were genotyped for methylenetetrahydrofolate dehydrogenase (MTHFD1) 1958G > A, methylenetetrahydrofolate reductase (MTHFR) 677C > T and 1298A > C and thymidylate synthase (TYMS) 2R > 3R polymorphisms. 22074251 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants have produced contradictory or inconclusive results. 22094326 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Seventy-two children with ALL and 109 age- and sex-matched healthy children from Western Iran were screened for MTHFR C677T and A1298C variants by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). 22017305 2012
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE For the MTHFR A1298C polymorphism, no significant association with ALL susceptibility was observed in the pooled analyses. 21702646 2011
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE No significant relation was found between MTHFR A1298C polymorphism and the risks of therapy induced complications or relapse rate in the studied ALL patients. 19923983 2010
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE We conducted a case-control study in 95 north Indian children with acute lymphoblastic leukemia (ALL) and 255 controls, to investigate the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of ALL. 20367562 2010
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL). 20374270 2010
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE DNA samples taken from patients with ALL and controls were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays to detect the MTHFR C677T and A1298C mutations. 17970089 2007
Childhood Acute Lymphoblastic Leukemia
0.100 GeneticVariation BEFREE Most studies found a strong association between the polymorphisms MTHFR, C677T or A1298C, and NQO1*2 or *3 and the risk of acute lymphoblastic leukemia (ALL). 17023046 2006