|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our study confirms the protective effect of MUC1 rs40</span>72037 polymorphism on the risk of GC under the dominant model.
|
28489708 |
2018 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our data suggested that rs4072037 polymorphism was associated with a decreased risk of GC.
|
28561882 |
2017 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive.
|
26910281 |
2016 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers.
|
26129866 |
2016 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
|
26910281 |
2016 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer.
|
27127881 |
2016 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Several genetic variants including PSCA rs2294008 C>T and rs2976392 G>A, MUC1 rs4072037 T>C, and PLCE1 rs2274223 A>G have shown significant association with stomach cancer risk in the previous genome-wide association studies (GWASs).
|
25658482 |
2015 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Further, subgroup analysis based on ethnicity suggested MUC1 rs4072037 polymorphism had a subtly reduced cancer risk among Asian population, and stratified analysis by cancer types showed significantly decreased risk of gastric cancer in all genetic models.
|
24755768 |
2014 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that the rs4072037 AG genotype was significantly associated with a reduced risk of gastric cancer [odds ratios (OR) = 0.78; 95% confidence interval (CI) = 0.67-0.91 for AG vs AA].
|
24254309 |
2014 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population.
|
24254309 |
2014 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
|
25503145 |
2014 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The G allele of MUC1 rs4072037 was significantly associated with a decreased risk of GC (OR = 0.72, 95 % CI 0.68-0.77; P = 7.82 × 10(-25)), as compared with A allele.
|
24072653 |
2013 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings indicate that the three SNPs (rs4072037, rs13361707 and rs2274223) identified in the GWASs may interact with H. pylori infection to increase the risk of GC.
|
24069371 |
2013 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings for rs4072037 and the risk of GC are in agreement with one previous report for a Caucasian population.
|
22805490 |
2012 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model.
|
22938415 |
2012 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that rs4072037 at 1q22 and rs2274223 at 10q23 were significantly associated with risk of GC with per allele odds ratio (OR) of 0.72 [95% confidence interval (CI): 0.63-0.81; P = 2.98 × 10(-7)] and 1.42 (95% CI: 1.27-1.58; P = 9.68 × 10(-10)), respectively.
|
21427165 |
2011 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer.
|
21070779 |
2011 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
|
22037551 |
2011 |
|
Stomach Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
|
20729852 |
2010 |