rs4420638, APOC1

N. diseases: 43
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation BEFREE The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD). 29942042 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation BEFREE The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline. 31760383 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities. 30636644 2019
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. 26830138 2016
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation BEFREE Our case-control study shows that rs4420638 genotype AA has a significant association with the concentrations of circulating HDL-C and APOA-I in CHD in Han Chinese males. 26535656 2015
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Genome-wide association analysis of age-at-onset in Alzheimer's disease. 22005931 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Genome-wide association study of Alzheimer's disease. 22832961 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Genome-wide association study of Alzheimer's disease. 22832961 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Genome-wide association analysis of age-at-onset in Alzheimer's disease. 22005931 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.820 GeneticVariation BEFREE SNPs rs6700896 in LEPR (OR, 1.06; 95% CI, 1.02 to 1.09; per minor allele), rs4537545 in IL6R (OR, 0.94; 95% CI, 0.91 to 0.97), and rs4420638 in the APOE-CI-CII cluster (OR, 1.16; 95% CI, 1.12 to 1.21) were all associated with risk of coronary heart disease. 19567438 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. 19734903 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Sorl1 as an Alzheimer's disease predisposition gene? 17975299 2008
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. 17998437 2008
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Sorl1 as an Alzheimer's disease predisposition gene? 17975299 2008
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. 17998437 2008
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. 17474819 2007
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. 17474819 2007
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.810 GeneticVariation BEFREE Nineteen single nucleotide polymorphisms (SNPs) previously associated with AMD, including rs10490924 (<i>ARMS2/HTRA1</i>), rs10737680 (<i>CFH</i>), rs13278062 (<i>TNFRSF10A</i>), rs1864163 (<i>CETP</i>), rs2230199 (<i>C3</i>), rs3130783 (<i>IER3/DDR1</i>), rs334353 (<i>TGFBR1</i>), rs3812111 (<i>COL10A1</i>), rs429608 (<i>C2/CFB</i>), rs4420638 (<i>APOE</i>), rs4698775 (<i>CFI</i>), rs5749482 (<i>TIMP3</i>), rs6795735 (<i>ADAMTS9</i>), rs8017304 (<i>RAD51B</i>), rs8135665 (<i>SLC16A8</i>), rs920915 (<i>LIPC</i>), rs943080 (<i>VEGFA</i>), rs9542236 (<i>B3GALTL</i>) and rs13081855 (<i>COL8A1/FILIP1L</i>), were genotyped in this cohort. 31819893 2019
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.810 GeneticVariation GWASDB Seven new loci associated with age-related macular degeneration. 23455636 2013
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.810 GeneticVariation GWASCAT Seven new loci associated with age-related macular degeneration. 23455636 2013
High density lipoprotein measurement
0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019