Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM.
|
31299695 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05).
|
24280871 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
|
22961080 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
|
22961080 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
COL8A1 rs792837 (P=2.9 × 10(-9)), KCNQ1 rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4 rs729287 (Pc=7.5 × 10(-5)), and HNF1 rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans.
|
24145053 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
|
22325160 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
Besides, the haplotype-based analysis demonstrated that AGT in block rs752010-rs4430796-rs7501939 was associated with about 30% increase in T2D risk (OR 1.31, 95% CI 1.09-1.57, P = 0.01).
|
23300827 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
|
21499250 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
Where type 2 diabetes was the outcome, only one statistically significant interaction effect was observed, and this was for the HNF1B rs4430796 variant (P(interaction) = 0.0004).
|
19324937 |
2009 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
Consistent with the initial study, we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds ratio 1.16 [95% CI 1.05-1.29], P = 0.0035, empirical P = 0.0475).
|
19168595 |
2009 |
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
|
31562322 |
2019 |
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR = 1.247, p = 2.21 × 10<sup>- 77</sup>) and endometrial cancer (OR = 1.217, p = 8.98 × 10<sup>- 16</sup>); the AA, AG genotypes also showed strong significant associations with the risk of prostate cancer (OR1 = 1.517, p = 4.46 × 10<sup>- 22</sup>; OR2 = 1.180, p = 0.002).
|
30053805 |
2018 |
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR = 1.247, p = 2.21 × 10<sup>- 77</sup>) and endometrial cancer (OR = 1.217, p = 8.98 × 10<sup>- 16</sup>); the AA, AG genotypes also showed strong significant associations with the risk of prostate cancer (OR1 = 1.517, p = 4.46 × 10<sup>- 22</sup>; OR2 = 1.180, p = 0.002).
|
30053805 |
2018 |
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results suggested that the HNF1B rs4430796 (A>G) polymorphism decreased the risk of prostate cancer.
|
26214421 |
2015 |
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
|
26443449 |
2015 |
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our results suggested that the HNF1B rs4430796 (A>G) polymorphism decreased the risk of prostate cancer.
|
26214421 |
2015 |
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
After subgroup analyses stratified by ethnicity, however, the rs4430796 polymorphism was significantly associated with prostate cancer in both Caucasians and Asians but not in African-Americans.
|
25177939 |
2014 |
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa.
|
24627192 |
2014 |
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa.
|
24627192 |
2014 |
Prostate carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
After subgroup analyses stratified by ethnicity, however, the rs4430796 polymorphism was significantly associated with prostate cancer in both Caucasians and Asians but not in African-Americans.
|
25177939 |
2014 |
Malignant neoplasm of prostate
|
|
0.800 |
GeneticVariation
|
BEFREE |
Individuals with the rs4430796 TT genotype were at increased CaP risk in the Chinese via a recessive model (odds ratios (OR) = 1.56, 95% CI = 1.04-2.33).
|
22561070 |
2013 |