rs4430796, HNF1B

N. diseases: 14
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation BEFREE The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [<i>PTGS2</i> (<i>COX2</i>) rs6681231, <i>FADS1</i> rs174550, <i>HNF1B</i> rs4430796, <i>ADIPOQ</i> rs266729, <i>IL18</i> rs187238, <i>CCL2</i> rs1024611, <i>HHEX</i> rs5015480 and <i>CDKN2A/2B</i> rs10811661] together with clinical risk factors (BMI and age) may significantly improve the prediction of GDM. 31299695 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation BEFREE Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05). 24280871 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation GWASCAT A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation GWASDB A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation BEFREE COL8A1 rs792837 (P=2.9 × 10(-9)), KCNQ1 rs2237892 (P=1.8 × 10(-18)) and rs2237895 (P=0.002), ALX4 rs729287 (Pc=7.5 × 10(-5)), and HNF1 rs4430796 (P=0.003) were significantly associated with T2DM, with similar effect sizes to those of Europeans. 24145053 2013
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation BEFREE Besides, the haplotype-based analysis demonstrated that AGT in block rs752010-rs4430796-rs7501939 was associated with about 30% increase in T2D risk (OR 1.31, 95% CI 1.09-1.57, P = 0.01). 23300827 2012
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation BEFREE We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes. 21499250 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation BEFREE Where type 2 diabetes was the outcome, only one statistically significant interaction effect was observed, and this was for the HNF1B rs4430796 variant (P(interaction) = 0.0004). 19324937 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.870 GeneticVariation BEFREE Consistent with the initial study, we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds ratio 1.16 [95% CI 1.05-1.29], P = 0.0035, empirical P = 0.0475). 19168595 2009
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.800 GeneticVariation GWASCAT 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 31562322 2019
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.800 GeneticVariation BEFREE Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR = 1.247, p = 2.21 × 10<sup>- 77</sup>) and endometrial cancer (OR = 1.217, p = 8.98 × 10<sup>- 16</sup>); the AA, AG genotypes also showed strong significant associations with the risk of prostate cancer (OR1 = 1.517, p = 4.46 × 10<sup>- 22</sup>; OR2 = 1.180, p = 0.002). 30053805 2018
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.800 GeneticVariation BEFREE Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR = 1.247, p = 2.21 × 10<sup>- 77</sup>) and endometrial cancer (OR = 1.217, p = 8.98 × 10<sup>- 16</sup>); the AA, AG genotypes also showed strong significant associations with the risk of prostate cancer (OR1 = 1.517, p = 4.46 × 10<sup>- 22</sup>; OR2 = 1.180, p = 0.002). 30053805 2018
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.800 GeneticVariation GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.800 GeneticVariation BEFREE Our results suggested that the HNF1B rs4430796 (A>G) polymorphism decreased the risk of prostate cancer. 26214421 2015
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.800 GeneticVariation GWASCAT Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. 26443449 2015
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.800 GeneticVariation BEFREE Our results suggested that the HNF1B rs4430796 (A>G) polymorphism decreased the risk of prostate cancer. 26214421 2015
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.800 GeneticVariation BEFREE After subgroup analyses stratified by ethnicity, however, the rs4430796 polymorphism was significantly associated with prostate cancer in both Caucasians and Asians but not in African-Americans. 25177939 2014
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.800 GeneticVariation BEFREE The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa. 24627192 2014
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.800 GeneticVariation BEFREE The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa. 24627192 2014
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.800 GeneticVariation BEFREE After subgroup analyses stratified by ethnicity, however, the rs4430796 polymorphism was significantly associated with prostate cancer in both Caucasians and Asians but not in African-Americans. 25177939 2014
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.800 GeneticVariation BEFREE Individuals with the rs4430796 TT genotype were at increased CaP risk in the Chinese via a recessive model (odds ratios (OR) = 1.56, 95% CI = 1.04-2.33). 22561070 2013