|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
The meta-analysis results demonstrated that TCF7L2 rs4506565, rs7901695, rs11196205 and rs12255372 polymorphisms were all significantly associated with susceptibility to T2DM in general population.
|
31288068 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
Our results revealed a strong association between risk T alleles in variants rs12255372 (OR: G/T=1.4233; T/T=2.0395) and rs4506565 (OR: A/T=1.6066; T/T=3.1301) and T2DM among the Saudi population of the Eastern Province of Saudi Arabia.
|
26367734 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
Given the overlap between PCOS and T2DM, we investigated the association of transcription factor-7-like 2 (TCF7L2) variants rs4506565, rs7903146, rs12243326, and rs12255372 with the susceptibility to PCOS.
|
24157263 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
The four tested TCF7L2 variants were in linkage disequilibrium, and 4-locus (rs4506565, rs7903146, rs12243326, rs12255372) haplotype analysis demonstrated that haplotype 1111 was negatively associated (Pc<0.001), while haplotypes 2222 (Pc=0.008) and 2211 (Pc=0.020) were positively associated with T2DM risk, after controlling for a number of covariates.
|
23142382 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
Significant associations were found between the six polymorphisms (rs7903146, rs12255372, rs11196205, rs7901695, rs7895340 and rs4506565) in the TCF7L2 gene and type 2 diabetes</span> risk, and the other two polymorphisms (rs11196218 and rs290487) were not found to be significantly associated with type 2 diabetes.
|
23188737 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
We found that SNPs rs7901695, rs4506565, rs7903146 and rs12255372 in the TCF7L2 gene were strongly associated with T2D (p<0.004).
|
19053027 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.870 |
GeneticVariation
|
BEFREE |
The overall evidence for association for these variants (P = 4.4 x 10(-14) combining case-control and family-based analyses for rs4506565) exceeds genome-wide significance criteria and clearly establishes TCF7L2 as a type 2 diabetes susceptibility gene of substantial importance.
|
16936215 |
2006 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.
|
31021400 |
2019 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
|
25631608 |
2015 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Coronary heart disease
|
|
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
20081858 |
2010 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Triglycerides measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Cerebrovascular accident
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Malignant Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Atrial Fibrillation
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |