|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sixty-four outpatients with BD in full or partial remission were stratified according to COMT Val158Met genotype (ValVal [n=13], ValMet [n=34], and MetMet [n=17]).
|
28544426 |
2017 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The COMT Val158Met Polymorphism Is Associated With Response to Add-on Dextromethorphan Treatment in Bipolar Disorder.
|
27930497 |
2017 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity.
|
27458023 |
2017 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission.
|
28049082 |
2017 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD.
|
25766270 |
2015 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global CD during manic and mixed episodes in BD.
|
22713126 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy controls were genotyped for COMT rs4680 and assessed for FER using the Ekman 60 Faces (EK60) and Emotion Hexagon (Hx) tests.
|
22222175 |
2012 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives.
|
20667170 |
2011 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We suggest that rs4680 could be an inheritable aspect of the mechanisms of dopamine regulation that influence the individual susceptibility of patients with bipolar disorder to develop manic episodes of illness.
|
21397335 |
2011 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response.
|
20004480 |
2010 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We suggest that rs4680 could be an inheritable aspect of the mechanisms of dopamine regulation that could influence the individual susceptibility of patients with bipolar disorder to develop psychotic symptoms.
|
20122740 |
2010 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the low-activity allele (Met) of rs4680 in COMT gene possibly confers risk for bipolar disorder in the Han population, while it needs further evidence for concluding its association with BP in the Caucasian population.
|
19578924 |
2009 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder.
|
18571901 |
2008 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltransferase (MB-COMT) due to altered promoter methylation and the nature of the contribution of COMT Val158Met polymorphism as risk factors for schizophrenia and bipolar disorder by analyzing 115 post-mortem brain samples from the frontal lobe.
|
16984965 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both the COMT Val158Met polymorphism and serological evidence of HSV-1 infection affect cognitive functioning in individuals with bipolar disorder.
|
16542182 |
2006 |
|
Bipolar Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |