|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Logistic regressions with interaction terms (adjusted for sex and age) revealed that rs4680 interacted with total childhood adversity, emotional abuse and physical abuse in predicting panic disorder: Respective childhood adversities predicted panic disorder in carriers of the Val/Met or Met/Met genotype, but not Val/Val genotype.
|
29574383 |
2018 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this age- and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD.
|
28096880 |
2017 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs4680 in COMT and rs3219151 in GABRA6 showed positive associations with PD and MDD.
|
25974322 |
2015 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
We compared gender-specific personality-related psychological factors of 470 individuals with panic disorder and 458 healthy controls in terms of their COMT Val158Met polymorphism and their scores on the Revised NEO Personality Inventory (NEO PI-R) and State-Trait Anxiety Inventory (STAI) with a 1-way analysis of covariance.
|
24852514 |
2014 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
These data suggested that COMT rs4680 could affect the white matter connectivity in panic disorder.
|
23141115 |
2013 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant relationship was found between the COMT Val158Met polymorphism and PD.
|
22036916 |
2012 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val(158)Met polymorphism in patients with panic disorder.
|
19900710 |
2010 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a replication.
|
20457471 |
2010 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been implicated in susceptibility to PD by several studies in independent samples and confirmed in a recent meta-analysis.
|
20048750 |
2010 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task: near-infrared spectroscopy study.
|
19429001 |
2009 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data provide preliminary evidence for a role of the functional val158met COMT polymorphism in amygdala and prefrontal activation in response to emotional faces in panic disorder.
|
18440204 |
2008 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD.
|
18832011 |
2008 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, given the relatively small number of case-control studies presently available, several more association studies, preferably including a larger number of family-based studies, are warranted for conclusive evaluation of the COMT val158met polymorphism as a vulnerability factor in panic disorder.
|
17357147 |
2007 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women.
|
15009906 |
2004 |
|
Panic Disorder
|
|
0.100 |
GeneticVariation
|
BEFREE |
A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the coding sequence of the catechol-O-methyltransferase (COMT) gene leads to a three- to fourfold difference in enzymatic activity and clinical and animal studies suggest a role in anxiety states like panic disorder.
|
11950461 |
2002 |