rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis. 28608575 2018
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts. 27203226 2016
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior. 24389396 2014
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders. 24708432 2014
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. 23799032 2013
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages. 22070166 2012
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure. 22138198 2012
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE On the other hand, preferential transmission of COMT rs4680 A allele and A-A haplotype (P<0.05) was observed specifically in male IID probands without any behavioral problem. 21609749 2011
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene. 21231925 2011
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. 21486391 2011
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE COMT Val158Met genotype as a risk factor for problem behaviors in youth. 20643317 2010
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele. 18384078 2008