rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE In conclusion, the COMT Val(158)Met polymorphism may constitute a genetic risk factor for psychotic symptoms in the context of combined exposure to childhood maltreatment and cannabis use. 23954148 2013
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE Further examination of this interaction revealed that in patients with the MTHFR 677 T-allele, COMT Met/Met individuals displayed the largest increases in psychotic symptoms in reaction to ESM stress [χ(2)(2) = 29.51; P < 0.0001], whereas in patients with the MTHFR 677 C/C genotype no significant COMT Val158Met × ESM stress interaction was apparent [χ(2)(2) = 3.65; P = 0.16]. 22128864 2012
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE In contrast to previous findings, analysis by logistic regression failed to find any associations between rs4680 and psychotic symptoms. 23069674 2012
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE In patients affected by bipolar disorder rs4680 can influence antidepressant response and the propensity to develop psychotic symptoms, with the Met/Met genotype exerting a protective role. 21397335 2011
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE We suggest that rs4680 could be an inheritable aspect of the mechanisms of dopamine regulation that could influence the individual susceptibility of patients with bipolar disorder to develop psychotic symptoms. 20122740 2010
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms. 17525974 2008
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE Our results show an influence of the Val 158 Met polymorphism on the severity of psychotic symptoms and on the response to treatment. 17363961 2007
Psychotic symptom
CUI: C0871189
Disease: Psychotic symptom
0.080 GeneticVariation BEFREE The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms. 17640440 2007