rs4680, COMT;MIR4761

N. diseases: 249
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The primary aim of this study was to investigate the effects of the catechol-O-methyltransferase Val</span>158Met polymorphism on heat pain perception in a cohort of adults receiving daily opioid therapy for chronic pain. 31041874 2020
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.100 GeneticVariation BEFREE COMT Val158Met (rs4680), DBH rs1611115 (also called -1021C/T or -970C/T), and MAOB rs1799836 (also called A644G) polymorphisms have been previously associated with AD. 31771069 2020
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Further the study suggested that evaluation of G472A allele of Mb.COMT gene in the patients undergoing sternotomy for monitoring pain in pre and post-surgical events. 30073475 2019
Malignant neoplasm of breast
CUI: C0006142
Disease: Malignant neoplasm of breast
0.100 GeneticVariation BEFREE There was no association between rs4680 and rs1056836 genotypes and adduct ratios or breast cancer status. 30525503 2019
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children's Math Anxiety. 31156495 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The Val158Met polymorphism (rs4680) does not appear to be involved in predisposition to tension-type headache; however, this genetic factor may be involved in the pathogenesis expression of CTTH, as greater pressure pain sensitivity and higher depressive levels were found in CTTH carrying the Met/Met genotype. 30614828 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.100 GeneticVariation BEFREE Our data support the role of COMT, and particularly of rs4680, in the pathogenesis of AD. 31096213 2019
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. 30084963 2019
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828 2019
Nonorganic psychosis
CUI: C0349204
Disease: Nonorganic psychosis
0.100 GeneticVariation BEFREE The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. 30084963 2019
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828 2019
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.100 GeneticVariation BEFREE A preliminary study suggested that the COMTVal108/158Met genotype (rs4680) is related to cognitive function in schizophrenia. 30326466 2019
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.100 GeneticVariation BEFREE There was no association between rs4680 and rs1056836 genotypes and adduct ratios or breast cancer status. 30525503 2019
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.100 GeneticVariation BEFREE This study indicated a significantly closer association between COMT Val158Met polymorphism and PD in the Japanese and Indian populations compared with other ethnicities. 30644790 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The association between COMT Val158Met polymorphism (rs4680) and the inter-individual differences in the response to opioid analgesic therapy was investigated in a cohort of 87 Italian paediatric patients receiving opioids for cancer pain (STOP Pain study). 30704436 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing. 31269327 2019
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.100 GeneticVariation BEFREE We have prospectively demonstrated the relationship between the single-nucleotide polymorphism of the Val158Met COMT gene (rs4680) and the hippocampal subfields in drug-naive MDD patients. 31239688 2019
Unipolar Depression
CUI: C0041696
Disease: Unipolar Depression
0.100 GeneticVariation BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol. 31806881 2019
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. 30614828 2019
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.100 GeneticVariation BEFREE Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children's Math Anxiety. 31156495 2019
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.100 GeneticVariation BEFREE We investigated the associations of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> with youth-onset schizophrenia in the Russian population in a case-control study, and the role of the genotype in the severity of clinical features. 31798476 2019
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.100 GeneticVariation BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
Pain
CUI: C0030193
Disease: Pain
0.100 GeneticVariation BEFREE The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype. 30481348 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.100 GeneticVariation BEFREE Although the triple-network model is important for a diagnosis of Alzheimer's disease, our results validated the role of the dorsal-putaminal-anchored network by the catechol-O-methyltransferase Val158Met polymorphism in predicting the severity of cognitive and behavior in subjects with Alzheimer's disease. 28707072 2018