Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have investigated the relationship between manganese superoxide dismutase (MnSOD) Val16Ala polymorphism and prostate cancer susceptibility, but the results have remained controversial.
|
27055786 |
2016 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among patients who underwent RT in the test cohort, there was a significant association between 3 of the 7 SOD2 SNPs and lethal prostate cancer: rs6917589 (overall P = .006), rs2758331 (P = .04) and the functional valine to alanine polymorphism in rs4880 (P = .04).
|
25662905 |
2015 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we performed integrated in vivo and in vitro protocols that analyzed the association between Ala16Val-SOD2 polymorphism and prostate cancer aggressiveness at the time of diagnosis and evaluated the effect of the imbalance on PC proliferation using the DU-145 PC cell line treated with paraquat and porphyrin.
|
26468117 |
2015 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer.
|
24610081 |
2014 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
Statistically significant effect modification of both HCA (DiMeIQx) and darkly browned meat intake and PCa risk was observed for allelic variants of MnSOD (rs4880) (P(interaction): 0.02).
|
22564066 |
2012 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
We previously reported a statistically significant interaction between circulating selenium levels, variants in the superoxide dismutase 2 gene (SOD2; rs4880), and risk of developing prostate cancer and presenting with aggressive prostate cancer.
|
20477822 |
2011 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
A high tertile selenium level in combination with non-wt rs125701 of the OGG1 gene in combination with smoking status or rs4880 related variation of MnSOD gene appeared to protect from PrCa.
|
21982398 |
2011 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
MnSOD Val16Ala polymorphism and prostate cancer susceptibility: a meta-analysis involving 8,962 subjects.
|
20012093 |
2010 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
Manganese superoxide dismutase (MnSOD) Val16Ala polymorphism has been recently associated with breast and prostate cancer.
|
18553161 |
2009 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant association was found between the Ala-9Val and Ala-16Val polymorphisms in MnSOD and prostate cancer susceptibility.
|
19647296 |
2009 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
Selenium status also modifies the effect of the mitochondrial superoxide dismutase (SOD2) SNP Ala16Val on prostate cancer risk.
|
19074884 |
2008 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this cohort of mainly white men, the MnSOD gene Ala16Val polymorphism was not associated with total or aggressive prostate cancer risk.
|
18784358 |
2008 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations between MPO -463 G to A genotype (rs2333227) and prostate cancer risk were only noted among men with aggressive cancer, with more than a 2-fold risk reduction among men with AA genotypes (OR = 0.4, 95% CI = 0.2-1.0); MnSOD was not associated with risk overall, but the MnSOD T to C (Val-9Ala, rs4880) polymorphism modified associations between risk of clinically aggressive prostate cancer and dietary iron intake (P for interaction = 0.02).
|
18296681 |
2008 |
Malignant neoplasm of prostate
|
|
0.100 |
GeneticVariation
|
BEFREE |
The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03).
|
17646272 |
2007 |