Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Previous studies have investigated the relationship between manganese superoxide dismutase (MnSOD) Val16Ala polymorphism and prostate cancer susceptibility, but the results have remained controversial. 27055786 2016
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Among patients who underwent RT in the test cohort, there was a significant association between 3 of the 7 SOD2 SNPs and lethal prostate cancer: rs6917589 (overall P = .006), rs2758331 (P = .04) and the functional valine to alanine polymorphism in rs4880 (P = .04). 25662905 2015
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Here, we performed integrated in vivo and in vitro protocols that analyzed the association between Ala16Val-SOD2 polymorphism and prostate cancer aggressiveness at the time of diagnosis and evaluated the effect of the imbalance on PC proliferation using the DU-145 PC cell line treated with paraquat and porphyrin. 26468117 2015
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer. 24610081 2014
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Statistically significant effect modification of both HCA (DiMeIQx) and darkly browned meat intake and PCa risk was observed for allelic variants of MnSOD (rs4880) (P(interaction): 0.02). 22564066 2012
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE We previously reported a statistically significant interaction between circulating selenium levels, variants in the superoxide dismutase 2 gene (SOD2; rs4880), and risk of developing prostate cancer and presenting with aggressive prostate cancer. 20477822 2011
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE A high tertile selenium level in combination with non-wt rs125701 of the OGG1 gene in combination with smoking status or rs4880 related variation of MnSOD gene appeared to protect from PrCa. 21982398 2011
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE MnSOD Val16Ala polymorphism and prostate cancer susceptibility: a meta-analysis involving 8,962 subjects. 20012093 2010
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Manganese superoxide dismutase (MnSOD) Val16Ala polymorphism has been recently associated with breast and prostate cancer. 18553161 2009
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE No significant association was found between the Ala-9Val and Ala-16Val polymorphisms in MnSOD and prostate cancer susceptibility. 19647296 2009
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Selenium status also modifies the effect of the mitochondrial superoxide dismutase (SOD2) SNP Ala16Val on prostate cancer risk. 19074884 2008
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE In this cohort of mainly white men, the MnSOD gene Ala16Val polymorphism was not associated with total or aggressive prostate cancer risk. 18784358 2008
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE Associations between MPO -463 G to A genotype (rs2333227) and prostate cancer risk were only noted among men with aggressive cancer, with more than a 2-fold risk reduction among men with AA genotypes (OR = 0.4, 95% CI = 0.2-1.0); MnSOD was not associated with risk overall, but the MnSOD T to C (Val-9Ala, rs4880) polymorphism modified associations between risk of clinically aggressive prostate cancer and dietary iron intake (P for interaction = 0.02). 18296681 2008
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.100 GeneticVariation BEFREE The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03). 17646272 2007