|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population.
|
30587704 |
2019 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.
|
29263402 |
2017 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese.
|
24804228 |
2014 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |