rs4977574, CDKN2B-AS1

N. diseases: 26
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population. 30587704 2019
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension. 29791233 2018
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE The rs4977574 with G allele may confer to a higher risk of CAD, especially MI. 30278588 2018
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease. 29894795 2018
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation GWASCAT Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. 29263402 2017
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis. 25268619 2014
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese. 24804228 2014
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans. 23364394 2013
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study. 23343465 2013
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation BEFREE Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification. 23561647 2013
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.890 GeneticVariation GWASDB Genomewide association analysis of coronary artery disease. 17634449 2007
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease. 29894795 2018
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE The rs4977574 with G allele may confer to a higher risk of CAD, especially MI. 30278588 2018
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE We showed a significant interaction between SSB intake and one of the 3 variants (i.e., rs4977574) on MI risk. 26961926 2016
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI. 25738804 2015
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time. 24475106 2014
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification. 23561647 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE PCR-RFLP revealed that the frequency of rs4977574, the MI-associated allele (G), was 56.8% (25/44) in patients with MI and 33.9% (9.5/28) in controls; the frequency of rs4977574 in patients with MI was significantly higher compared to controls (P = 0.027). 23856978 2013
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation BEFREE One marker, rs6922269, in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086). 22216278 2011
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation GWASCAT Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. 19198609 2009
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation GWASDB Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. 19198609 2009
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.880 GeneticVariation GWASDB A common variant on chromosome 9p21 affects the risk of myocardial infarction. 17478679 2007
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.840 GeneticVariation BEFREE ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12,005 subjects. 30278588 2018
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.840 GeneticVariation BEFREE The frequencies of the rs4977574 genotypes and alleles between CHD and control groups, and the rs2740483 genotypes and alleles between IS and control groups were different (p = 0.006-0.001). 27096864 2016