rs4986790, TLR4

N. diseases: 223
Disease: Ankylosing spondylitis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.760 GeneticVariation BEFREE The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS. 27692393 2018
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.760 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.760 GeneticVariation BEFREE The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility. 22717291 2012
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.760 GeneticVariation BEFREE The minor allele frequency for the Asp299Gly variant (G) was significantly higher in AS cases compared to controls (7.5% vs 2.6%, respectively; OR 3.10, p = 0.037). 17143969 2007
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.760 GeneticVariation BEFREE No significant difference between the frequencies of the Asp299Gly genotype or the Thr399Ile genotype between patients with AS and healthy HLA-B27 controls was found. 16837493 2006
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.760 GeneticVariation BEFREE Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibility in either AS or ReA. 16567359 2006
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.760 GeneticVariation BEFREE There is no evidence for involvement of the CD14 C-260T or TLR4 A896G polymorphisms in susceptibility to AS. 15647432 2005