rs53576, OXTR;CAV3

N. diseases: 42
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE We tested whether the rs53576 polymorphism in the oxytocin receptor (OXTR) gene accounts for variation in the impact of low social support as a risk factor for depression among mothers during the perinatal period. 30928624 2019
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE Given the bi-directional nature of mother-infant influences on maternal mood, we tested the association between both mothers' and infants' OXTR_rs53576 genotype and maternal depression, as assessed through a self-report inventory. 31755553 2019
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE A single-nucleotide polymorphism (SNP) of the oxytocin receptor gene (OXTR), rs53576, and a SNP of the CD38 gene, which regulates oxytocin secretion, rs3796863, have been associated with depression and suicidal ideation. 29860184 2018
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE These results suggest that rs53576 variants confer vulnerability for depression within the context of interpersonal risk factors, such that youth with the GG genotype may be particularly sensitive to the social consequences resulting from RA. 28868757 2018
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE To replicate and extend these findings, we examined whether three literature-based OXTR SNPs (rs2254298, rs53576, rs2268498) interact with childhood maltreatment in the development of clinically diagnosed depression and anxiety disorders. 28353027 2017
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE Our results show that the OXTR rs53576 variant modulates the mood in male individuals and may positively correlate with alcohol intake among male suicides, but is not associated with suicide or depression. 28024273 2017
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443). 28499211 2017
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE Exon 2 methylation was associated with OXTR rs53576 genotype but not with depression</span>. 25890851 2015
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.090 GeneticVariation BEFREE Consistent with an interpersonal perspective on depression, the present study focused on a genetic polymorphism that has been shown to be relevant to social functioning, the rs53576 polymorphism of the oxytocin receptor gene (OXTR). 24703166 2014