rs5498, ICAM4;ICAM1

N. diseases: 99
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Blood Protein Measurement
CUI: C2985280
Disease: Blood Protein Measurement
0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
Lymphocyte Count measurement
CUI: C0200635
Disease: Lymphocyte Count measurement
0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE As their main finding, they concluded that 'K469E polymorphism is associated with CHD risk and the K allele is a more significant risk factor for developing CHD amongst Chinese and Caucasians populations'. 31072912 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE The ICAM1 rs5498 might be a susceptible factor for T2D, but not T1D. 30798334 2019
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE The pooled result showed that the <i>ICAM-1</i> gene E469K</span> polymorphism was significantly associated with an increased risk of CHD (OR = 1.20, 95% CI = 1.11-1.29, for the allele K versus allele E; OR = 1.66, 95% CI = 1.43-1.92, for the K allele carriers versus EE). 30674642 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies. 30419874 2018
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease. 30290609 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE The EE genotype of the rs5498 of the ICAM-1 gene was associated with a more rapid progression of carotid atherosclerosis in patients with T2DM in comparison with other genotypes. 27090396 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE Our results revealed that SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort. 26717491 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE Association between the ICAM-1 K469E polymorphism and diabetic retinopathy in Type 2 diabetes mellitus: a meta-analysis. 24612665 2014
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE Intercellular adhesion molecule-1 K469E polymorphism and risk of coronary artery disease: a meta-analysis. 25503951 2014
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE The ICAM-1 K469E polymorphism is associated with the risk of coronary artery disease: a meta-analysis. 25025994 2014
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE In conclusion, it was demonstrated in the present study that the rs5498 polymorphism of the ICAM‑1 gene was associated with CHD in males. 24993975 2014
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE Intercellular adhesion molecule-1 E469K gene polymorphism and coronary artery disease in the Chinese population: a meta-analysis involving 3065 subjects. 21987404 2012
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE The pooled result showed that the ICAM1 gene-E469K</span> polymorphism was significantly associated with an increased risk of CHD (OR = 1.496, 95% CI = 1.363-1.642, for the allele K vs. allele E; OR = 1.919, 95% CI = 11.635-2.253, for the K allele carriers vs. EE). 22203486 2012
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.090 GeneticVariation BEFREE Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease. 19048183 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE We may conclude that the EE genotype of the K469E polymorphism of the ICAM-1 might be a risk factor for PDR in the Slovenian population (Caucasians) with type 2 diabetes. 18942221 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE The ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. 16759306 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE In conclusion, the K469</span>E polymorphism of the ICAM-1 gene was not associated with MI in patients with type 2 diabetes, and therefore may not be used as a genetic marker for MI in patients with type 2 diabetes. 17089918 2006
Diabetes Mellitus, Non-Insulin-Dependent
0.090 GeneticVariation BEFREE The K469E polymorphism of the intercellular adhesion molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes. 15736117 2005
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.060 GeneticVariation BEFREE In conclusion, this meta-analysis indicates that ICAM-1 gene rs5498 polymorphism decreases the risk of CAD. 30290609 2018
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.060 GeneticVariation BEFREE ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease. 30290609 2018
Diabetic Retinopathy
CUI: C0011884
Disease: Diabetic Retinopathy
0.060 GeneticVariation BEFREE Our meta-analyses provide no evidence of the association of rs5498 with DR in type 2 diabetic patients. 30419874 2018
Diabetic Retinopathy
CUI: C0011884
Disease: Diabetic Retinopathy
0.060 GeneticVariation BEFREE Our results revealed that SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort. 26717491 2016
Inflammatory Bowel Diseases
CUI: C0021390
Disease: Inflammatory Bowel Diseases
0.060 GeneticVariation BEFREE The polymorphisms K469E and G261R of intercellular adhesion molecule-1 and susceptibility to inflammatory bowel disease: a meta-analysis. 25942347 2015