rs572842823, APP

N. diseases: 11
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cognition Disorders
CUI: C0009241
Disease: Cognition Disorders
0.020 GeneticVariation BEFREE In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L). 22212065 2012
Cognition Disorders
CUI: C0009241
Disease: Cognition Disorders
0.020 GeneticVariation BEFREE Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V). 15578094 2004