Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety
CUI: C0003467
Disease: Anxiety
0.040 GeneticVariation BEFREE The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits. 22940476 2013
Anxiety
CUI: C0003467
Disease: Anxiety
0.040 GeneticVariation BEFREE A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia. 20334879 2010
Anxiety
CUI: C0003467
Disease: Anxiety
0.040 GeneticVariation BEFREE Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype. 20520601 2010
Anxiety
CUI: C0003467
Disease: Anxiety
0.040 GeneticVariation BEFREE At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6). 18305461 2008