|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders.
|
30998730 |
2019 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse.
|
29649711 |
2018 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
|
29288952 |
2018 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) is associated with psychiatric disorders and regional gray matter volume (rGMV) in adults.
|
26830347 |
2016 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we comprehensively review the role and relevance of the Val66Met polymorphism in psychiatric disorders, with emphasis on suicidal behavior and anxiety, eating, mood and psychotic disorders.
|
25824305 |
2015 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity.
|
24708359 |
2015 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Val66Met (also known as rs6265 or G196A), the only known functional polymorphism of the BDNF gene, has been widely studied and considered to be associated with risk of some psychiatric disorders such as bipolar disorder and schizophrenia.
|
26503495 |
2015 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Using clinical data and DNA samples from mouthwash gathered from an epidemiological study on the prevalence of mental disorders in youths between 12 and 17 years old, we tested the statistical interaction between a set of psychosocial adversities experienced during childhood (CAs) with two common polymorphisms in the brain-derived neurotrophic factor (BDNF) (Val66Met) and SLC6A4 (L/S) genes on the probability of suffering MDD in adolescence.
|
24683520 |
2014 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies show that the Val(66)Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies.
|
24051499 |
2013 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely.
|
19896331 |
2010 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein.
|
19603419 |
2010 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (val66met) in the brain derived neurotrophic factor (BDNF) gene has been shown to be a risk factor for a number of psychiatric disorders, including schizophrenia.
|
20957650 |
2010 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein.
|
19603419 |
2010 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
G196A, a common polymorphism of the BDNF gene, not only affects cognitive and motor processes, but also is associated with various psychiatric disorders.
|
20085561 |
2010 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (rs6265) in the human gene, resulting in a valine to methionine substitution in the pro-BDNF protein, was thought to associate with psychiatric disorders and might play roles in the individual difference of cognitive abilities.
|
19424874 |
2009 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Altered hippocampal volume, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and neuroticism have each been implicated in the etiology of psychiatric disorders, especially depression.
|
18548532 |
2009 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of the valine/methionine variant at codon 66 (Val66Met) of brain derived neurotrophic factor (BDNF) has been reported inconsistently across a spectrum of psychiatric disorders.
|
18797396 |
2008 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis restricted to individual case-control studies in different categories of mental disorders and BDNF Val66Met polymorphism.
|
17217930 |
2007 |
|
Mental disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders.
|
15537879 |
2004 |