rs6265, BDNF;BDNF-AS

N. diseases: 272
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly. 31771052 2020
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cog</span>nitive impairment in PD, especially in Caucasian populations. 31365694 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Functional rs6265 polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in posttraumatic stress disorder among Chinese patients with hepatocellular carcinoma. 30659644 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research. 31104169 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers. 30775992 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism. 30659208 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE. 29952080 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE While the BDNF polymorphism (rs6265) is associated with faster cognitive decline and increased hippocampal atrophy, a replicable genetic association of BDNF with AD risk has yet to be demonstrated. 30909233 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy. 30382534 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE <i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory. 29423073 2018
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Several heritability studies have reported that the Brain Derived Neurotrophic Factor (<i>BDNF</i>) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. 30333719 2018
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults. 28099630 2017
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics. 28468845 2017
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Our results do not support that the common genetic risk variants in rs6265 and rs1006737 are associated with cognitive dysfunction. 27221213 2016
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD. 26806863 2016
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer. 26289590 2016
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia. 26603624 2016
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE This study investigated the effects of BDNF Val66Met polymorphism on functional magnetic resonance imaging (fMRI) during n-back WM tasks in healthy middle-aged adults.A total of 110 participants without subjective or objective cognitive impairment underwent BDNF genotyping. 26496261 2015
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression. 26000753 2015
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE We investigated whether a common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated with individual differences in cognitive decline (marked by perceptual speed) in old age. 24660789 2014
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD. 24862657 2014
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role. 24275008 2014
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease. 24394906 2014
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment. 23769397 2013
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism. 22362486 2012