|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
A fixed-effect model was chosen, and the pooled result showed that rs6296 was not related to al</span>coholism (z = 1.93, <i>p</i> = .053).
|
31510870 |
2019 |
|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
The aim of this study is to investigate the role of the most relevant variants (rs11568817, rs130058, rs6296 and rs13212041) of the HTR1B gene in the susceptibility to alcohol dependence.
|
22005095 |
2012 |
|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our study suggests that neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism.
|
22550993 |
2012 |
|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
No significant association of the genotype or allele frequencies of the h5-HTR(1B) G861C locus was observed with diagnoses of alcoholism, bipolar disorder, schizophrenia or a history of a suicide attempt.
|
12496953 |
2003 |
|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
There exists preliminary evidence for association of G861C with i) antisocial alcoholism in the Finnish; ii) alcoholism in the presence of inactive aldehyde dehydrogenase 2 in the Japanese; iii) a history of suicide attempts in European-American personality disorder patients; and iv) minimum lifetime body mass index in Canadian bulimia nervosa patients.
|
12437478 |
2002 |
|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
Consequently, genes encoding serotonin (5-HT) receptors are candidates for genetic studies of both disorders. found evidence for linkage of antisocial alcoholism to HTR1B (the locus encoding the 5-HT1B receptor) in both Finns and Southwestern American Indians, and of allelic association of a G861C polymorphism at that locus with antisocial alcoholism in Finns.
|
11751038 |
2002 |
|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy.
|
11104852 |
2000 |
|
Alcoholic Intoxication, Chronic
|
|
0.080 |
GeneticVariation
|
BEFREE |
In the Southwestern American Indian tribe, significant sib pair linkage of antisocial alcoholism</span> to HTR1B G861C (P=.01) was again observed, and there was also significant linkage to D6S284 (P=.01).
|
9819067 |
1998 |
|
Attention deficit hyperactivity disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
The results showed that the 861G allele of 5-HTR1B SNP rs6296 could significantly increase the risk of ADHD (C)R=1.09, 95% CI: 1.01-1.18); the 5-HTR2C gene rs518147 (OR=1.69, 95% CI: 1.38-2.07) and rs3813929 (OR = 1.57, 95% CI: 1.25-1.97) were all associated with the risk of ADHD.
|
30074224 |
2018 |
|
Attention deficit hyperactivity disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
Taking into account the well-known sexual dimorphic effect observed in serotonergic system characteristics, we differentially tested the influence of HTR1B SNPs (rs11568817, rs130058, rs6296 and rs13212041) on ADHD susceptibility and on its major comorbidities according to sex.
|
28923721 |
2017 |
|
Attention deficit hyperactivity disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
We measured neural activation during stop-signal task performance in adolescents with ADHD (N = 185), their unaffected siblings (N = 111), and healthy controls (N = 124), and investigated the relationship of two serotonin gene polymorphisms (the rs6296 SNP of the HTR1B gene and HTTLPR variants of the 5-HTT gene) with the neural correlates of response inhibition.
|
26428549 |
2015 |
|
Attention deficit hyperactivity disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
We used the transmission disequilibrium test (TDT) and haplotype analysis to investigate the A-161T and G861C polymorphisms in the 5-HT1B receptor gene in ADHD trios from the Chinese Han population.
|
15578608 |
2005 |
|
Attention deficit hyperactivity disorder
|
|
0.050 |
GeneticVariation
|
BEFREE |
We tested for linkage disequilibrium between the 5-HT1B G861C polymorphism and ADHD in 115 families using the transmission disequilibrium test (TDT).
|
12556913 |
2003 |
|
Headache
|
|
0.030 |
GeneticVariation
|
BEFREE |
Gene polymorphisms including serotonin (5-HT)(1B) receptor G861C and dopamine receptor 2 (DRD2) C939T, personality traits and characteristics of headache were investigated in 46 consistent responders and 14 inconsistent responders to triptans.
|
21822697 |
2012 |
|
Antisocial behavior
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, we examined whether the 5-HTTLPR gene and 5-HT1B gene G861C polymorphism are susceptibility factors for a specific subtype of alcoholism, antisocial alcoholism in Han Chinese in Taiwan.
|
22550993 |
2012 |
|
Headache
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, a positive association of the CC genotype of the G861C polymorphism of the 5-HT1B receptor with the reported intensity of the headache attack on the visual analogue scale was observed (CC 8.3 +/- 1.5 vs. GG 6.9 +/- 1.8; p < 0.05).
|
17417740 |
2007 |
|
Antisocial behavior
|
|
0.030 |
GeneticVariation
|
BEFREE |
Consequently, genes encoding serotonin (5-HT) receptors are candidates for genetic studies of both disorders. found evidence for linkage of antisocial alcoholism to HTR1B (the locus encoding the 5-HT1B receptor) in both Finns and Southwestern American Indians, and of allelic association of a G861C polymorphism at that locus with antisocial alcoholism in Finns.
|
11751038 |
2002 |
|
Headache
|
|
0.030 |
GeneticVariation
|
BEFREE |
Allele frequencies of two polymorphisms in the 5-HT1B receptor gene (G861C and T-261G) were investigated in migraine patients with consistently good response to sumatriptan (n = 14), with no response (n = 12), with recurrence of the headache (n = 12), with chest symptoms (n = 13), and in patients without chest symptoms (n = 27).
|
9595868 |
1998 |
|
Antisocial behavior
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the Southwestern American Indian tribe, significant sib pair linkage of antisocial alcoholism to HTR1B G861C (P=.01) was again observed, and there was also significant linkage to D6S284 (P=.01).
|
9819067 |
1998 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs6296-C allele lowered the level of HTR1B mRNA, causing individuals with MDD to display more hostility and aggressive behavior, which may lead to suicidal ideation.
|
28007644 |
2017 |
|
Abnormal behavior
|
|
0.020 |
GeneticVariation
|
BEFREE |
And the silent mutation G861C allele has been reported to be associated with several psychiatric disorders.
|
15698927 |
2005 |
|
Mental disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
And the silent mutation G861C allele has been reported to be associated with several psychiatric disorders.
|
15698927 |
2005 |
|
Mental disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
Interestingly, G861C has been reported to be associated with several psychiatric disorders.
|
14593427 |
2003 |
|
Major Depressive Disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism.
|
12496953 |
2003 |
|
Abnormal behavior
|
|
0.020 |
GeneticVariation
|
BEFREE |
Interestingly, G861C has been reported to be associated with several psychiatric disorders.
|
14593427 |
2003 |