rs7193343, ZFHX3

N. diseases: 3
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation BEFREE Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis. 31169720 2019
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation BEFREE Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF). 25684755 2015
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation BEFREE In Caucasian population, genetic variant rs7193343 SNP is associated with risk of AF in Caucasian population. 26112950 2015
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation BEFREE Variants rs2200733 and rs7193343 are associated with a higher risk of atrial fibrillation. 25262128 2014
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation BEFREE All the polymorphisms tested (except rs17570669) correlated significantly with AF in univariate analysis (p values between 0.039 for rs7193343 and 2.7e-27 for rs2200733), with the odds ratio (OR) 0.572 and 0.617 for rs3853445 and rs6838973, respectively (protective role) and OR 1.268 to 3.52 for the other polymorphisms. 21760908 2011
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation BEFREE Recent genome-wide association studies (GWAS) identified two single nucleotide polymorphisms (SNPs), rs2106261 and rs7193343 in ZFHX3 (zinc finger homeobox 3 gene) and rs13376333 in KCNN3 (encoding a potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) that showed significant association with AF in multiple populations of European ancestry. 21107608 2011
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation BEFREE A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). 19597491 2009
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation GWASDB A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). 19597491 2009
Atrial Fibrillation
CUI: C0004238
Disease: Atrial Fibrillation
0.870 GeneticVariation GWASCAT A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). 19597491 2009