|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
BEFREE |
The haplotype tagged by rs35923643-G (or its proxy SNP rs735665-A) is also known as the top risk allele for chronic lymphocytic leukemia (CLL), and a main increasing allele for general IgM.
|
29547969 |
2018 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
|
24292274 |
2014 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
|
24292274 |
2014 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
|
23770605 |
2013 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
|
23770605 |
2013 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASDB |
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
|
22700719 |
2012 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
|
22700719 |
2012 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
BEFREE |
Common single nucleotide polymorphisms (SNPs) at 2q13 (rs17483466), 2q37.1 (rs13397985), 2q37.3 (rs757978), 6p25.3 (rs872071), 8q24.21 (rs2456449), 11q24.1 (rs735665), 15q21.3 (rs7169431), 15q23 (rs7176508), 16q24.1 (rs305061), and 19q13.32 (rs11083846) have been shown to confer a modest but significant increase in CLL risk.
|
20855867 |
2010 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
BEFREE |
Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk.
|
20553269 |
2010 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASCAT |
We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)).
|
18758461 |
2008 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
BEFREE |
We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)).
|
18758461 |
2008 |
|
Chronic Lymphocytic Leukemia
|
|
0.840 |
GeneticVariation
|
GWASDB |
We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)).
|
18758461 |
2008 |
|
Small Lymphocytic Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
|
24292274 |
2014 |
|
Small Lymphocytic Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
|
23770605 |
2013 |
|
Erectile dysfunction
|
|
0.700 |
GeneticVariation
|
GWASDB |
Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.
|
22704111 |
2012 |
|
Small Lymphocytic Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
|
22700719 |
2012 |
|
Nasopharyngeal carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
Mature B-Cell Neoplasm
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
|
20639881 |
2010 |
|
Lymphoma, Follicular
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
|
20639881 |
2010 |
|
Small Lymphocytic Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
|
18758461 |
2008 |
|
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).
|
20639881 |
2010 |
|
Monoclonal B-Cell Lymphocytosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
An association between genotype and MBL risk was seen for 9 SNPs, 6 of which were statistically significant: rs17483466 (odds ratio [OR] =1.27; P = .02), rs13397985 (OR = 1.40; P = 1.72 × 10(-3)), rs757978 (OR = 1.38; P = .02), rs872071 (OR = 1.27; P = 7.75 × 10(-3)), rs2456449 (OR = 1.31; P = 3.14 × 10(-3)), and rs735665 (OR = 1.63; P = 6.86 × 10(-6)).
|
20855867 |
2010 |