|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of HSD17B13 rs72613567:TA was associated with a lower risk for both ci</span>rrhosis (OR 0.79 [95% CI 0.72-0.88], p=8.13×10-6) and HCC (OR 0.77 [95% CI 0.68-0.89], p=2.27×10-4), while carriage of PNPLA3 rs738409:G was associated with an increased risk for developing cirrhosis (OR 1.70 [95% CI 1.54-1.88], p=1.52x10-26) and HCC (OR 1.77 [95% CI 1.58-1.98], p=2.31×10-23).
|
31630428 |
2019 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age.
|
31527889 |
2019 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 I148M was associated with a stepwise increase in liver fat content of up to 28% in MM vs. II-homozygotes (P-trend = 0.0001) and with ORs of 2.03 (1.52-2.70) for NAFLD (P = 3×10-7), 3.28 (2.37-4.54) for cirrhosis (P = 4×10-12), and 0.95 (0.86-1.04) for IHD (P = 0.46).
|
29228164 |
2018 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In multivariate analysis adjusted by the main clinical and epidemiological covariates, the rs738409 G allele was related to higher increase of LSM values during the follow-up (adjusted arithmetic mean ratio (aAMR) = 1.16 (95%CI = 1.04; 1.29); p = .006) and higher odds of having progression to advanced fibrosis [aOR = 2.03 (95%CI = 1.01; 4.06); p = .045], and progression to cirrhosis [aOR = 3.03 (95%CI = 1.26; 7.30); p = .014].
|
29674183 |
2018 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variants in patatin-like phospholipase domain-containing 3 (PNPLA3; rs738409), transmembrane 6 superfamily member 2 (TM6SF2; rs58542926), and membrane bound O-acyltransferase domain containing 7 (MBOAT7; rs641738) are risk factors for the development of alcohol-related cirrhosis.
|
29535416 |
2018 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the PNPLA3 rs738409 G allele has been associated with the risk of steatosis in CHB patients, no association between this polymorphism and the risk of cirrhosis was seen.
|
29218813 |
2018 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study showed that PNPLA3 rs738409 and RNF7 rs16851720 confer an increased risk of developing liver fibrosis and cirrhosis in this Eastern European population, while the MERTK and PCSK7 SNPs are not associated with these conditions.
|
28338112 |
2017 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of rs738409:G in PNPLA3 is associated with an increased risk of developing alcohol-related cirrhosis and has a significant negative effect on survival.
|
28161471 |
2017 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 270 HBV-infected patients, concurrent fatty liver was found in 107 patients (39.6%) and was associated with metabolic risks, cirrhosis (P = 0.016) and PNPLA3 rs738409 CG/GG genotype (P = 0.002).
|
27547913 |
2017 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Only rs738409 was associated with cirrhosis: 45 (29.6%) of 152 G allele carriers versus 36 (20.0%) of 180 CC carriers showed cirrhosis (multivariate p = 0.018; adjusted odds ratio = 1.98; 95% confidence interval = 1.12-3.50).
|
27973562 |
2016 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 C > G polymorphism is associated with the risk of progression to cirrhosis in NAFLD patients.
|
27150500 |
2016 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 CG/GG SNP at rs738409 was significantly associated with the presence of cirrhosis (odds ratio [OR], 1.76; 95% confidence interval [CI], 1.34-2.30), after adjusting for age, sex, diabetes, and race.
|
26305067 |
2016 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that patients at risk for liver cirrhosis may benefit from PNPLA3 genotyping and thus more intensive monitoring if the rs738409 C>G polymorphism is identified.
|
25378656 |
2015 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We identified variants in the MBOAT7 (P = 1.03 × 10(-9)) and TM6SF2 (P = 7.89 × 10(-10)) genes as new risk loci and confirmed rs738409 in PNPLA3 as an important risk locus for alcohol-related cirrhosis (P = 1.54 × 10(-48)) at a genome-wide level of significance.
|
26482880 |
2015 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.
|
24114809 |
2014 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, using two histologically characterized cohorts encompassing steatosis, steatohepatitis, fibrosis and cirrhosis (combined n=1,074), we demonstrate a new association, independent of potential confounding factors (age, BMI, type 2 diabetes mellitus and PNPLA3 rs738409 genotype), with advanced hepatic fibrosis/cirrhosis.
|
24978903 |
2014 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association among age at onset of at-risk alcohol consumption, PNPLA3 I148M variant and cirrhosis incidence was tested.
|
24102786 |
2014 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409 genotypes were assessed in 279 patients with alcoholic- and 253 patients with HCV-related cirrhosis.
|
23069476 |
2013 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, the I148M variant represents a major determinant of progression of alcohol related steatohepatitis to cirrhosis, and to influence fibrogenesis and related clinical outcomes in chronic hepatitis C virus hepatitis, and possibly chronic hepatitis B virus hepatitis, hereditary hemochromatosis and primary sclerosing cholangitis.
|
24222941 |
2013 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
According to ultrasound examinations, no association between PNPLA3 rs738409 genotype and fatty change of the liver or hepatic cirrhosis was found in Japanese patients infected with HCV.
|
24349054 |
2013 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis.
|
22719190 |
2012 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The -1195GG genotype of single nucleotide polymorphism (SNP) in COX-2 promoter was associated with low platelet counts in patients with chronic hepatitis C. Polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene (rs738409 C>G) have been reported to be associated with cirrhosis, and the major genotype of SNPs near interleukin (IL)28B are related to viral clearance.
|
22863264 |
2012 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies of the PNPLA3 I148M sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis.
|
22978414 |
2012 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis.
|
22560221 |
2012 |