|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
ALT was significantly associated with variants at reported genetic loci for alcoholic liver disease (PNPLA3, rs738409, p = 0.0076; TM6SF2, rs10401969, p = 0.0076; HSD17B13, rs10433879, p = 0.0024).
|
30589442 |
2019 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males.
|
30132178 |
2018 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The adiponutrin (PNPLA3) p.I148M and transmembrane 6 superfamily member 2 (TM6SF2) p.E167K variants represent major genetic risk factors for progressive liver injury in nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) and chronic viral hepatitis.
|
30161167 |
2018 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
ADPN I148M polymorphism has been consistently reported to play a role in liver-associated diseases, such as alcoholic liver disease, chronic hepatitis C, and liver fat and fibrosis in nonalcoholic fatty liver disease.
|
26632699 |
2015 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The nonsynonymous single-nucleotide polymorphism rs738409 C > G in the patatin-like phospholipase domain-containing 3 gene (PNPLA3, also known as adiponutrin), encoding the I148 M protein variant, has been identified as a novel genetic marker for hepatic steatosis and fibrosis in nonalcoholic fatty liver disease and alcoholic liver disease.
|
25543233 |
2015 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although to date only Adiponutrin (PNPLA3) rs738409 polymorphism (I148M) had been unequivocally proved to be associated with increased risk of alcoholic liver disease across different ethnicities.
|
26519102 |
2015 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies have reported an association between alcoholic liver cirrhosis (ALC) or other forms of alcoholic liver disease (ALD) and the genetic variant rs738409 (C>G) in adiponutrin/patatin-like phospholipase domain-containing 3 gene (PNPLA3).
|
25060292 |
2014 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G allele of the I148M variant was significantly overrepresented in patients with alcoholic liver disease (ALD, P < 0.001) and associated with hepatocellular carcinoma (HCC) development (odds ratio [OR] = 2.399; 95% confidence interval [CI]: 1.292-4.455; P = 0.008) while not affecting the other liver disease entities.
|
25273282 |
2014 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs738409 variant (I148M) of the PNPLA3 gene is associated with alcoholic and non-alcoholic liver disease and we evaluated its impact on the disease course of PSC.
|
23505555 |
2013 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with hepatic fat accumulation and disease progression in patients with non-alcoholic fatty liver disease and alcoholic liver disease (ALD).
|
22869157 |
2013 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the PNPLA3 single-nucleotide polymorphism rs738409 (M148I) was reported to be associated with advanced alcoholic liver disease in alcohol-dependent individuals of Mestizo descent.
|
21254164 |
2011 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated with non-alcoholic fatty liver disease and with alcoholic liver disease.
|
21745286 |
2011 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease.
|
21893698 |
2011 |
|
Alcoholic Liver Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have identified the variant p.I148M of the adiponutrin gene PNPLA3 as a risk factor for developing severe forms of non-alcoholic and alcoholic liver diseases.
|
21168459 |
2011 |