rs738409, PNPLA3

N. diseases: 88
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Metabolic syndrome (MetS) and genetic polymorphisms PNPLA3 rs738409, TM6SF2 rs58542926 and MBOAT7 rs641738 are known inductors of non-alcoholic fatty liver disease (NAFLD). 31851849 2019
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE PNPLA3 I148M is associated with increased risk of prediabetes, metabolic syndrome and insulin resistance in obese patients with NAFLD. 31826069 2019
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE PNPLA3 rs738409 Polymorphism Predicts Development and Severity of Hepatic Steatosis but Not Metabolic Syndrome in Celiac Disease. 30189691 2018
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The I148M variant in PNPLA3 and the E167K variant in TM6SF2 are both associated with increased liver fat content, but not features of the metabolic/insulin resistance syndrome. 27432073 2016
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Such potential examples of genotypes that are associated with a dissociation between liver disease and metabolic syndrome are patatin-like phospholipase domain-containing protein-3 (PNPLA3) (I148M) and transmembrane 6 superfamily member 2 protein (TM6SF2) (E167K) genotypes. 26978356 2016
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The PNPLA3 rs738409 polymorphism is associated already in youths with increased ALT, and is more frequent in obese with MetS of all ages. 25939720 2015
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Modern noninvasive liver graft assessment frequently detects hepatic steatosis, which is associated with graft fibrosis, components of the metabolic syndrome and recipient PNPLA3 rs738409 genotype, especially in ALC patients. 25429378 2015
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE First, we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148M variant and the presence of metabolic syndrome on the association between PNPLA3 I148M and NAFLD. 25624712 2015
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The G allele in PNPLA3 rs738409 increases the risk of NAFLD in the general population, especially in subjects without metabolic syndrome, independent of dietary pattern and metabolic factors. 24417250 2014
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Age and HOMA-IR were positive independent predictors of metabolic syndrome, while a negative independent association was found between metabolic syndrome and the homozygotes PNPLA3 I148M variant. 24947770 2014
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE In Inter99, we analyzed associations of rs738409 with components of the WHO-defined metabolic syndrome (n = 5,847) and traits related to metabolic disease (n = 5,663). 22792295 2012