Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicated that the <i>PNPLA3</i> rs738409 polymorphism may serve as a potential biological marker of hepatocellular carcinoma in Caucasians.
|
30852978 |
2019 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expandable primary human (upcyte®) hepatocytes and human PLC/PRF/5 hepatoma cells were lentivirally transduced with both PNPLA3 I148M variants and stimulated with lipids.
|
31637480 |
2019 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, PNPLA3 rs738409 C > G polymorphism may be a risk factor for virus and alcoholic-related HCC.
|
30403964 |
2019 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
G allele of PNPLA3 rs738409 variant was significantly higher in NBNC-HCC (49%) compared to healthy controls (32%), HBV-HCC (32%) and HCV-HCC (31%) (P < 0.001).
|
30506232 |
2019 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of HSD17B13 rs72613567:TA was associated with a lower risk for both cirrhosis (OR 0.79 [95% CI 0.72-0.88], p=8.13×10-6) and HCC (OR 0.77 [95% CI 0.68-0.89], p=2.27×10-4), while carriage of PNPLA3 rs738409:G was associated with an increased risk for developing cirrhosis (OR 1.70 [95% CI 1.54-1.88], p=1.52x10-26) and HCC (OR 1.77 [95% CI 1.58-1.98], p=2.31×10-23).
|
31630428 |
2019 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, PNPLA3-rs738409 and TM6SF2-rs58542926 are inherited risk variants of HCC development in patients with ALD in a dose dependent manner.
|
30289982 |
2019 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this longitudinal study with liver biopsy to stage liver fibrosis, we affirm there is no influence of the rs738409 (GG) genotype on the occurrence of HCC in Asian CHC patients, including cirrhotic patients.
|
29089161 |
2018 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of both PNPLA3 rs738409 and TM6SF2 rs58542926 accounts for half of the attributable risk for HCC in this population.
|
29535416 |
2018 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patatin-like phospholipase domain containing 3 (PNPLA3) rs738409 (encoding the I148M variant) has been associated with advanced fibrosis and HCC.
|
27862719 |
2017 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC).
|
28928439 |
2017 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results demonstrate significant associations between both rs430397 and rs738409 and HCC development in a Sicilian cohort.
|
27888630 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) near the epidermal growth factor (EGF) (rs4444903), IL28B (rs12979860), and PNPLA3 (rs738409) loci are associated with treatment response, fibrosis, and hepatocellular carcinoma in non-transplant hepatitis C, but allograft population data are limited.
|
26854475 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study assessed the interaction between PNPLA3 rs738409 and TM6SF2 rs58542926 variants in the conditioning of HCC development.
|
26493626 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The SNP rs738409 located in PNPLA3 was the greatest risk factor associated with HCC.
|
26337813 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I148M variant has a strong impact on the full spectrum of liver damage related to fatty liver, encompassing non-alcoholic steatohepatitis, advanced fibrosis, and hepatocellular carcinoma, and influences the response to therapeutic approaches.
|
26409295 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on data from the HALT-C trial, the PNPLA3 CG/GG SNP at rs738409 is associated with fibrosis progression but not development of HCC in patients with HCV infection.
|
26305067 |
2016 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicates that I148M polymorphism in the ADPN gene may independently contribute to the progression of HCC irrespective of the etiologies.
|
26632699 |
2015 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
PNPLA3 genetic polymorphism (rs738409 C>G) is associated with increased risk for the entire spectrum of ALD among drinkers including ALI, AC, and HCC.
|
25964223 |
2015 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of rs738409 genotypes CC, CG and GG in controls was 91 (45.5%), 88 (44.0%), and 21 (10.5%), respectively, while the corresponding genotypes in all patients with HCC was 158 (40.7%), 178 (45.9%), and 52 (13.4%).
|
26745088 |
2015 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, these results suggest that rs738409 exerts a marked influence on hepatocarcinogenesis in patients with cirrhosis of European descent and provide a strong argument for performing further mechanistic studies to better understand the role of PNPLA3 in HCC development.
|
24114809 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Variation at rs738409 was not associated with significant changes in resolution rate of hepatitis C. By contrast, M/M genotype, present at higher frequencies (22.8%) in HCC patients than in patients with chronic hepatitis C (8.5%, P = 0.004) or control individuals (9.1%, P = 0.005) was associated with a 3-fold increase of liver cancer risk.
|
24269995 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The PNPLA3 I148M sequence variant favors hepatic lipid accumulation and confers susceptibility to hepatic fibrosis and hepatocellular carcinoma.
|
25171251 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In particular, the common I148M variant of the PNPLA3 gene influencing hepatic lipid metabolism influences HCC risk independently of its effect on the progression of liver fibrosis.
|
25278690 |
2014 |
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriage of the PNPLA3 rs738409 C >G polymorphism is not only associated with greater risk of progressive steatohepatitis and fibrosis but also of HCC.
|
24607626 |
2014 |