rs752021744, PIK3CB

N. diseases: 29
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Tumor Progression
CUI: C0178874
Disease: Tumor Progression
0.020 GeneticVariation BEFREE Additionally, we tested efficacy of PD-0325901 in Kras(G12D-LSL) conditional GEMMs (genetically engineered mouse models) which are a valuable tool in translational research to study tumor progression. 22684718 2012
Tumor Progression
CUI: C0178874
Disease: Tumor Progression
0.020 GeneticVariation BEFREE We hypothesized that tumor progression was because of concomitant activation of the mitogen-activated protein kinase pathway downstream of Kras(G12D) expression promoting cell survival and that the therapeutic effect of PF-04691502 would be enhanced by combinatory inhibition of MEK using PD-0325901. 21632463 2011