|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present study also indicates that <i>STAT4</i> rs7574865 polymorphism increased the risk of chronic HBV infection and HCC.
|
31160486 |
2019 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In contrast, STAT4-rs7574865 was associated with HCC only in HBV infected patients (p = 0.03) and the other tested SNP were not linked with HCC risk.
|
30289982 |
2019 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified that <i>STAT4</i>-rs7574865 polymorphism was significantly associated with an increased risk of HCC in allelic contrast, dominant, homozygote and recessive models.
|
30310516 |
2018 |
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
STAT4 polymorphism, rs7574865 is linked to various autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
|
27960128 |
2017 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
STAT4 polymorphism, rs7574865 is linked to various autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
|
27960128 |
2017 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study confirmed the association of STAT4 rs7574865 polymorphism with RA and was the first to indicate an association with RF and anti-CCP antibodies positivity.
|
28424905 |
2017 |
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent studies have indicated associations of rs7574865 single nucleotide polymorphism (SNP) in the STAT4 gene with various autoimmune diseases.
|
27126090 |
2017 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significantly increased risk of HCC associated with the rs7574865</span> G was found.
|
27126090 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We aimed to analyze three SNPs located in the <i>STAT4</i> (rs7574865), <i>ITGAM</i> (rs1143679) and <i>TNXB</i> (rs1150754) genes in both DLE and SLE patients from Poland.
|
28670251 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
STAT4 polymorphism, rs7574865 is linked to various autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
|
27960128 |
2017 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
A higher risk to develop RA was observed for rs7574865 in the STAT-4 gene, while the rs1800872 in the IL-10 gene showed a protective effect.
|
27342690 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
MDR analysis revealed significant gene-gene interactions among glutathione-S-transferase (GST)T1 and STAT4 (rs3821236 and rs7574865) polymorphisms, which account for moderate predictability of SLE.
|
26689915 |
2016 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Thus, the STAT4 rs7574865G/T polymorphism confers risk for RA and SLE in the Mexican population.
|
27178308 |
2016 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
This work supports the association of the STAT4 rs7574865 polymorphism with RA and disease activity, but not with anti-CCP antibody levels in a Mexican population.
|
27234231 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Thus, the STAT4 rs7574865G/T polymorphism confers risk for RA and SLE in the Mexican population.
|
27178308 |
2016 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study.
|
25665738 |
2015 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population.
|
25913043 |
2015 |
|
Autoimmune Diseases
|
|
0.900 |
GeneticVariation
|
BEFREE |
The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders.
|
26569609 |
2015 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P = 1.79 × 10(-2), OR = 1.17, 95% CI = 1.03-1.34; rs9267673: P = 4.91 × 10(-4), OR = 1.37, 95% CI = 1.15-1.63; rs2647073: P = 3.53 × 10(-5), OR = 1.63, 95% CI = 1.29-2.06; rs3997872: P = 4.22 × 10(-4), OR = 1.86, 95% CI = 1.32-2.62; rs9275319: P = 1.30 × 10(-2), OR = 1.32, 95% CI = 1.06-1.64).
|
26538132 |
2015 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data demonstrated positive association of rs7574865 with HCC risk when compared to healthy controls under an additive model (GG versus TT: odds ratio (OR) =2.07, 95% confidence interval (CI)=1.06-4.03, P=0.033).
|
26745093 |
2015 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis demonstrated that PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms confers susceptibility to RA in total subjects and in major ethnic groups.
|
25963842 |
2015 |
|
Rheumatoid Arthritis
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study indicates that the STAT4 rs7574865 G/T polymorphism was significantly associated with a decreased RA risk in an Asian population.
|
25179669 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR = 0.86, 95%CI = 0.62-1.19; meta-analysis, OR = 0.87, 95%CI = 0.74-1.03), which may be due to the small sample size.
|
25365208 |
2014 |